DegronMD

Uniprot ID: Q5JUQ0

Source protein: Protein FAM78A

Source gene: FAM78A

Class: DEG_SIAH_1

Location: 250:258

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.7782

ASA_SCORE: 54.9889

COIL: 0.6351

CONS_SCORE: 0.7802

DSS_SCORE: 0.5065

HELIX: 0.3384

FCONS_SCORE: 1.0034

RIG_SCORE: 0.695

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K245N	TCGA-AG-A002	READ	TCGA	PPSALVKPN	DEG_SIAH_1	0.3056
p.P250L	TCGA-AX-A3FT	UCEC	TCGA	PPSALVKPN	DEG_SIAH_1	0.6471
p.P250L	DO40801	UCEC	ICGC	PPSALVKPN	DEG_SIAH_1	0.6471
p.P250S	TCGA-CV-7568	HNSC	TCGA	PPSALVKPN	DEG_SIAH_1	0.5641
p.P250S	TCGA-E8-A2JQ	THCA	TCGA	PPSALVKPN	DEG_SIAH_1	0.5641
p.I242L	TCGA-GV-A3QK	BLCA	TCGA	PPSALVKPN	DEG_SIAH_1	0.1111
p.L262F	DO1071	BRCA	ICGC	PPSALVKPN	DEG_SIAH_1	0.2222
p.P247S	DO14160	HNSC	ICGC	PPSALVKPN	DEG_SIAH_1	0.25
p.P247S	DO39511	THCA	ICGC	PPSALVKPN	DEG_SIAH_1	0.25
p.S241I	DO228252	LICA	ICGC	PPSALVKPN	DEG_SIAH_1	0.5278
p.D258N	DO228390	LICA	ICGC	PPSALVKPN	DEG_SIAH_1	0.6932
p.I249T	DO232761	PBCA	ICGC	PPSALVKPN	DEG_SIAH_1	0.3056
p.Q263H	SIDM00429	B-Lymphoblastic Leukemia	GDSC	PPSALVKPN	DEG_SIAH_1	0.1944
p.Q263H	ACH-000938	Leukemia	CCLE	PPSALVKPN	DEG_SIAH_1	0.1944
p.Q263H	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	PPSALVKPN	DEG_SIAH_1	0.1944
p.S252N	SIDM01664	Prostate Carcinoma	GDSC	PPSALVKPN	DEG_SIAH_1	0.5958
p.S252N	ACH-000952	Prostate Cancer	CCLE	PPSALVKPN	DEG_SIAH_1	0.5958
p.Q260H	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	PPSALVKPN	DEG_SIAH_1	0.2778
p.P266L	ME-180	cervix	COSMIC	PPSALVKPN	DEG_SIAH_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JUQ0	Protein FAM78A	DEG_SIAH_1	250:258	PPSALVKPN	SIAH1,SIAH2,SIAH3	0.7782	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons