DegronMD

Uniprot ID: Q9Y3S1

Source protein: Serine/threonine-protein kinase WNK2

Source gene: WNK2

Class: DEG_SCF_FBW7_1

Location: 712:719

E3 ligase: FBXW7

DEGRON score: 0.8679

ASA_SCORE: 95.0625

COIL: 0.9703

CONS_SCORE: 0.2423

DSS_SCORE: 0.755

HELIX: 0.0081

FCONS_SCORE: 0.5746

RIG_SCORE: 0.4804

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A717S	DO18164	KIRC	ICGC	PPSTPMPT	DEG_SCF_FBW7_1	0.7588
p.P708R	DO24739	LUAD	ICGC	PPSTPMPT	DEG_SCF_FBW7_1	0.2222
p.G715R	DO51761	STAD	ICGC	PPSTPMPT	DEG_SCF_FBW7_1	0.7568
p.P716A	SIDM01313	Colorectal Carcinoma	GDSC	PPSTPMPT	DEG_SCF_FBW7_1	0.7503
p.P726T	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PPSTPMPT	DEG_SCF_FBW7_1	0.1389
p.P702S	SIDM00901	Endometrial Carcinoma	GDSC	PPSTPMPT	DEG_SCF_FBW7_1	0.0556
p.P702S	ACH-000940	Endometrial/Uterine Cancer	CCLE	PPSTPMPT	DEG_SCF_FBW7_1	0.0556
p.P702S	AN3-CA	endometrium	COSMIC	PPSTPMPT	DEG_SCF_FBW7_1	0.0556
p.A707T	ACH-000960	Leukemia	CCLE	PPSTPMPT	DEG_SCF_FBW7_1	0.1944
p.Q729L	ACH-002024	Colon/Colorectal Cancer	CCLE	PPSTPMPT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SCF_FBW7_1	712:719	PPSTPMPT	FBXW7	0.8679	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons