DegronMD

Uniprot ID: O15534

Source protein: Period circadian protein homolog 1

Source gene: PER1

Class: DEG_SCF_FBW7_1

Location: 863:870

E3 ligase: FBXW7

DEGRON score: 0.6352

ASA_SCORE: 96.1625

COIL: 0.9756

CONS_SCORE: 0.3856

DSS_SCORE: 0.5388

HELIX: 0.0094

FCONS_SCORE: 0.9911

RIG_SCORE: 0.5521

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P867L	ACH-000523	Lung Cancer	CCLE	PPSTPWPT	DEG_SCF_FBW7_1	0.7582
p.W868R	DO229121	THCA	ICGC	PPSTPWPT	DEG_SCF_FBW7_1	0.7523
p.T866P	DO224744	COCA	ICGC	PPSTPWPT	DEG_SCF_FBW7_1	0.7031
p.T866P	DO229148	THCA	ICGC	PPSTPWPT	DEG_SCF_FBW7_1	0.7031
p.T866P	DO229163	THCA	ICGC	PPSTPWPT	DEG_SCF_FBW7_1	0.7031
p.T866P	DO229253	THCA	ICGC	PPSTPWPT	DEG_SCF_FBW7_1	0.7031
p.T866P	DO229085	THCA	ICGC	PPSTPWPT	DEG_SCF_FBW7_1	0.7031
p.T870P	DO229133	THCA	ICGC	PPSTPWPT	DEG_SCF_FBW7_1	0.7031
p.T870P	DO229184	THCA	ICGC	PPSTPWPT	DEG_SCF_FBW7_1	0.7031
p.T870P	DO229121	THCA	ICGC	PPSTPWPT	DEG_SCF_FBW7_1	0.7031
p.T870P	DO229084	THCA	ICGC	PPSTPWPT	DEG_SCF_FBW7_1	0.7031
p.T870P	DO229087	THCA	ICGC	PPSTPWPT	DEG_SCF_FBW7_1	0.7031
p.V862A	DO233245	GACA	ICGC	PPSTPWPT	DEG_SCF_FBW7_1	0.3056
p.P871L	SIDM00730	Small Cell Lung Carcinoma	GDSC	PPSTPWPT	DEG_SCF_FBW7_1	0.3056
p.P871L	ACH-000610	Lung Cancer	CCLE	PPSTPWPT	DEG_SCF_FBW7_1	0.3056
p.P861S	SIDM01608	Endometrial Carcinoma	GDSC	PPSTPWPT	DEG_SCF_FBW7_1	0.2778
p.P861S	ACH-000990	Endometrial/Uterine Cancer	CCLE	PPSTPWPT	DEG_SCF_FBW7_1	0.2778
p.S860L	SIDM01662	Plasma Cell Myeloma	GDSC	PPSTPWPT	DEG_SCF_FBW7_1	0.25
p.S860L	ACH-000564	Myeloma	CCLE	PPSTPWPT	DEG_SCF_FBW7_1	0.25
p.T874P	DO228029	EOPC	ICGC	PPSTPWPT	DEG_SCF_FBW7_1	0.2222
p.P859S	DO27847	MALY	ICGC	PPSTPWPT	DEG_SCF_FBW7_1	0.2222
p.P859H	SIDM00499	Prostate Carcinoma	GDSC	PPSTPWPT	DEG_SCF_FBW7_1	0.2222
p.P859H	ACH-000956	Prostate Cancer	CCLE	PPSTPWPT	DEG_SCF_FBW7_1	0.2222
p.P859H	22RV1	prostate	COSMIC	PPSTPWPT	DEG_SCF_FBW7_1	0.2222
p.T875I	DO228955	LICA	ICGC	PPSTPWPT	DEG_SCF_FBW7_1	0.1944

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15534	Period circadian protein homolog 1	DEG_SCF_FBW7_1	863:870	PPSTPWPT	FBXW7	0.6352	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons