DegronMD

Uniprot ID: O15534

Source protein: Period circadian protein homolog 1

Source gene: PER1

Class: DEG_SCF_FBW7_1

Location: 863:870

E3 ligase: FBXW7

DEGRON score: 0.6352

ASA_SCORE: 96.1625

COIL: 0.9756

CONS_SCORE: 0.3856

DSS_SCORE: 0.5388

HELIX: 0.0094

FCONS_SCORE: 0.9911

RIG_SCORE: 0.5521

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S857L	TCGA-C8-A26Y	BRCA	TCGA	PPSTPWPT	DEG_SCF_FBW7_1	0.1667
p.S857L	DO1273	BRCA	ICGC	PPSTPWPT	DEG_SCF_FBW7_1	0.1667
p.Y855C	TCGA-CJ-4638	KIRC	TCGA	PPSTPWPT	DEG_SCF_FBW7_1	0.1111
p.Y855C	DO20022	KIRC	ICGC	PPSTPWPT	DEG_SCF_FBW7_1	0.1111
p.T866P	DO224744	COCA	ICGC	PPSTPWPT	DEG_SCF_FBW7_1	0.7031
p.T866P	DO229148	THCA	ICGC	PPSTPWPT	DEG_SCF_FBW7_1	0.7031
p.T866P	DO229163	THCA	ICGC	PPSTPWPT	DEG_SCF_FBW7_1	0.7031
p.T866P	DO229253	THCA	ICGC	PPSTPWPT	DEG_SCF_FBW7_1	0.7031
p.T866P	DO229085	THCA	ICGC	PPSTPWPT	DEG_SCF_FBW7_1	0.7031
p.T874P	DO228029	EOPC	ICGC	PPSTPWPT	DEG_SCF_FBW7_1	0.2222
p.V862A	DO233245	GACA	ICGC	PPSTPWPT	DEG_SCF_FBW7_1	0.3056
p.T875I	DO228955	LICA	ICGC	PPSTPWPT	DEG_SCF_FBW7_1	0.1944
p.S854L	DO50869	LICA	ICGC	PPSTPWPT	DEG_SCF_FBW7_1	0.0833
p.P859S	DO27847	MALY	ICGC	PPSTPWPT	DEG_SCF_FBW7_1	0.2222
p.T870P	DO229133	THCA	ICGC	PPSTPWPT	DEG_SCF_FBW7_1	0.7031
p.T870P	DO229184	THCA	ICGC	PPSTPWPT	DEG_SCF_FBW7_1	0.7031
p.T870P	DO229121	THCA	ICGC	PPSTPWPT	DEG_SCF_FBW7_1	0.7031
p.T870P	DO229084	THCA	ICGC	PPSTPWPT	DEG_SCF_FBW7_1	0.7031
p.T870P	DO229087	THCA	ICGC	PPSTPWPT	DEG_SCF_FBW7_1	0.7031
p.W868R	DO229121	THCA	ICGC	PPSTPWPT	DEG_SCF_FBW7_1	0.7523
p.F877L	DO229092	THCA	ICGC	PPSTPWPT	DEG_SCF_FBW7_1	0.1389
p.P859H	SIDM00499	Prostate Carcinoma	GDSC	PPSTPWPT	DEG_SCF_FBW7_1	0.2222
p.P859H	ACH-000956	Prostate Cancer	CCLE	PPSTPWPT	DEG_SCF_FBW7_1	0.2222
p.P859H	22RV1	prostate	COSMIC	PPSTPWPT	DEG_SCF_FBW7_1	0.2222
p.P871L	SIDM00730	Small Cell Lung Carcinoma	GDSC	PPSTPWPT	DEG_SCF_FBW7_1	0.3056
p.P871L	ACH-000610	Lung Cancer	CCLE	PPSTPWPT	DEG_SCF_FBW7_1	0.3056
p.P861S	SIDM01608	Endometrial Carcinoma	GDSC	PPSTPWPT	DEG_SCF_FBW7_1	0.2778
p.P861S	ACH-000990	Endometrial/Uterine Cancer	CCLE	PPSTPWPT	DEG_SCF_FBW7_1	0.2778
p.S860L	SIDM01662	Plasma Cell Myeloma	GDSC	PPSTPWPT	DEG_SCF_FBW7_1	0.25
p.S860L	ACH-000564	Myeloma	CCLE	PPSTPWPT	DEG_SCF_FBW7_1	0.25
p.P867L	ACH-000523	Lung Cancer	CCLE	PPSTPWPT	DEG_SCF_FBW7_1	0.7582
p.P879L	MCC13	skin	COSMIC	PPSTPWPT	DEG_SCF_FBW7_1	0.0833
p.P877A	MCC13	skin	COSMIC	PPSTPWPT	DEG_SCF_FBW7_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPSTPWPT

Degron related mutations and impact score

Drug responses associated with PER1 mutations

All proteins holding degron of PPSTPWPT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15534	Period circadian protein homolog 1	DEG_SCF_FBW7_1	863:870	PPSTPWPT	FBXW7	0.6352	More...