DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PPTPASS
Uniprot ID:
Q8N377
Source protein:
Putative uncharacterized protein LOC387726
Source gene:
-
Class:
DEG_SCF_FBW7_1
Location:
66:72
E3 ligase:
FBXW7
DEGRON score:
0.9916
ASA_SCORE:
80.2286
COIL:
0.9639
CONS_SCORE:
0
DSS_SCORE:
0.6079
HELIX:
0.021
FCONS_SCORE:
0
RIG_SCORE:
0.5526
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with - mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPTPASS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8N377
Putative uncharacterized protein LOC387726
DEG_SCF_FBW7_1
22:28
PPTPASS
FBXW7
0.9892
More...
Q8N377
Putative uncharacterized protein LOC387726
DEG_SCF_FBW7_1
33:39
PPTPASS
FBXW7
0.9892
More...
Q8N377
Putative uncharacterized protein LOC387726
DEG_SCF_FBW7_1
66:72
PPTPASS
FBXW7
0.9916
More...