DegronMD

Uniprot ID: Q8N6T7

Source protein: NAD-dependent protein deacylase sirtuin-6

Source gene: SIRT6

Class: DEG_SCF_FBW7_2

Location: 292:298

E3 ligase: FBXW7

DEGRON score: 0.8744

ASA_SCORE: 93.8286

COIL: 0.9651

CONS_SCORE: 0.4268

DSS_SCORE: 0.7333

HELIX: 0.0143

FCONS_SCORE: 1.0044

RIG_SCORE: 0.5911

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S303Y	TCGA-A5-A1OF	UCEC	TCGA	PPTPKLE	DEG_SCF_FBW7_2	0.6389
p.S303Y	DO42568	UCEC	ICGC	PPTPKLE	DEG_SCF_FBW7_2	0.6389
p.R291C	TCGA-D3-A8GO	SKCM	TCGA	PPTPKLE	DEG_SCF_FBW7_2	0.3056
p.R291C	DO51242	SKCM	ICGC	PPTPKLE	DEG_SCF_FBW7_2	0.3056
p.T294P	DO229133	THCA	ICGC	PPTPKLE	DEG_SCF_FBW7_2	0.8142
p.T294P	DO229180	THCA	ICGC	PPTPKLE	DEG_SCF_FBW7_2	0.8142
p.R291P	DO229180	THCA	ICGC	PPTPKLE	DEG_SCF_FBW7_2	0.3056
p.R291P	DO229253	THCA	ICGC	PPTPKLE	DEG_SCF_FBW7_2	0.3056
p.E301D	DO229272	THCA	ICGC	PPTPKLE	DEG_SCF_FBW7_2	0.25
p.L289P	DO229248	THCA	ICGC	PPTPKLE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N6T7	NAD-dependent protein deacylase sirtuin-6	DEG_SCF_FBW7_2	292:298	PPTPKLE	FBXW7	0.8744	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons