DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
PPTPRPT
Uniprot ID:
Q5JWF2
Source protein:
Guanine nucleotide-binding protein G
Source gene:
GNAS
Class:
DEG_SCF_FBW7_1
Location:
540:546
E3 ligase:
FBXW7
DEGRON score:
0.9879
ASA_SCORE:
86.2429
COIL:
0.948
CONS_SCORE:
0.421
DSS_SCORE:
0.7204
HELIX:
0.0256
FCONS_SCORE:
1.0208
RIG_SCORE:
0.6024
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with GNAS mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPTPRPT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5JWF2
Guanine nucleotide-binding protein G
DEG_SCF_FBW7_1
540:546
PPTPRPT
FBXW7
0.9879
More...