DegronMD

Uniprot ID: Q6ICB4

Source protein: Sesquipedalian-2

Source gene: PHETA2

Class: DEG_SCF_FBW7_1

Location: 33:39

E3 ligase: FBXW7

DEGRON score: 0.8548

ASA_SCORE: 79.8

COIL: 0.8254

CONS_SCORE: 0.2459

DSS_SCORE: 0.4607

HELIX: 0.0207

FCONS_SCORE: 0.3512

RIG_SCORE: 0.6285

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R41Q	SIDM02021	Esophageal Carcinoma	GDSC	PPTPSGT	DEG_SCF_FBW7_1	0.2778
p.G29S	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PPTPSGT	DEG_SCF_FBW7_1	0.2222
p.G29S	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	PPTPSGT	DEG_SCF_FBW7_1	0.2222
p.R42K	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPTPSGT	DEG_SCF_FBW7_1	0.25
p.R42K	A3-KAW	haematopoietic_and_lymphoid_tissue	COSMIC	PPTPSGT	DEG_SCF_FBW7_1	0.25
p.G28E	SIDM01177	B-Lymphoblastic Leukemia	GDSC	PPTPSGT	DEG_SCF_FBW7_1	0.1944
p.G28E	SUP-B8	haematopoietic_and_lymphoid_tissue	COSMIC	PPTPSGT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ICB4	Sesquipedalian-2	DEG_SCF_FBW7_1	33:39	PPTPSGT	FBXW7	0.8548	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons