DegronMD

Uniprot ID: Q68CJ9

Source protein: Cyclic AMP-responsive element-binding protein 3-like protein 3

Source gene: CREB3L3

Class: DEG_SCF_FBW7_1

Location: 97:104

E3 ligase: FBXW7

DEGRON score: 0.9959

ASA_SCORE: 80.025

COIL: 0.9488

CONS_SCORE: 0.389

DSS_SCORE: 0.85

HELIX: 0.0315

FCONS_SCORE: 1.0661

RIG_SCORE: 0.5189

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G88S	TCGA-38-4632	LUAD	TCGA	PQDTPPRS	DEG_SCF_FBW7_1	0.0833
p.E91K	TCGA-A5-A0G2	UCEC	TCGA	PQDTPPRS	DEG_SCF_FBW7_1	0.1667
p.A111T	TCGA-A5-A0G2	UCEC	TCGA	PQDTPPRS	DEG_SCF_FBW7_1	0.1389
p.R103C	TCGA-AA-A022	COAD	TCGA	PQDTPPRS	DEG_SCF_FBW7_1	0.719
p.R103C	SIDM00538	Esophageal Carcinoma	GDSC	PQDTPPRS	DEG_SCF_FBW7_1	0.719
p.R103C	ACH-001497	Esophageal Cancer	CCLE	PQDTPPRS	DEG_SCF_FBW7_1	0.719
p.R103C	ESO51	oesophagus	COSMIC	PQDTPPRS	DEG_SCF_FBW7_1	0.719
p.S109F	TCGA-BF-AAOX	SKCM	TCGA	PQDTPPRS	DEG_SCF_FBW7_1	0.1944
p.S109F	TCGA-EB-A431	SKCM	TCGA	PQDTPPRS	DEG_SCF_FBW7_1	0.1944
p.T108I	TCGA-C5-A3HF	CESC	TCGA	PQDTPPRS	DEG_SCF_FBW7_1	0.2222
p.G112S	TCGA-E3-A3DZ	THCA	TCGA	PQDTPPRS	DEG_SCF_FBW7_1	0.1111
p.G112S	SIDM00807	Bladder Carcinoma	GDSC	PQDTPPRS	DEG_SCF_FBW7_1	0.1111
p.P110L	TCGA-EB-A431	SKCM	TCGA	PQDTPPRS	DEG_SCF_FBW7_1	0.1667
p.T98I	DO49015	CESC	ICGC	PQDTPPRS	DEG_SCF_FBW7_1	0.7078
p.T98I	DO232042	ORCA	ICGC	PQDTPPRS	DEG_SCF_FBW7_1	0.7078
p.R93C	DO10647	COAD	ICGC	PQDTPPRS	DEG_SCF_FBW7_1	0.2222
p.R93C	DO233245	GACA	ICGC	PQDTPPRS	DEG_SCF_FBW7_1	0.2222
p.A101T	DO234320	ESAD	ICGC	PQDTPPRS	DEG_SCF_FBW7_1	0.7139
p.A101T	DO41235	UCEC	ICGC	PQDTPPRS	DEG_SCF_FBW7_1	0.7139
p.G109S	DO11411	GBM	ICGC	PQDTPPRS	DEG_SCF_FBW7_1	0.1944
p.G95R	DO229346	LAML	ICGC	PQDTPPRS	DEG_SCF_FBW7_1	0.2778
p.C113F	DO229015	LICA	ICGC	PQDTPPRS	DEG_SCF_FBW7_1	0.0833
p.S99F	DO220877	MELA	ICGC	PQDTPPRS	DEG_SCF_FBW7_1	0.7982
p.S99F	DO229456	SKCA	ICGC	PQDTPPRS	DEG_SCF_FBW7_1	0.7982
p.S99F	DO37671	SKCM	ICGC	PQDTPPRS	DEG_SCF_FBW7_1	0.7982
p.S99F	DO223907	SKCM	ICGC	PQDTPPRS	DEG_SCF_FBW7_1	0.7982
p.P100S	DO219878	SKCA	ICGC	PQDTPPRS	DEG_SCF_FBW7_1	0.6752
p.P100L	DO37671	SKCM	ICGC	PQDTPPRS	DEG_SCF_FBW7_1	0.7582
p.G102S	DO40215	THCA	ICGC	PQDTPPRS	DEG_SCF_FBW7_1	0.6993
p.G105R	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	PQDTPPRS	DEG_SCF_FBW7_1	0.3056
p.G105R	SIDM00297	Non-Small Cell Lung Carcinoma	GDSC	PQDTPPRS	DEG_SCF_FBW7_1	0.3056
p.G105R	SIDM00352	Ovarian Carcinoma	GDSC	PQDTPPRS	DEG_SCF_FBW7_1	0.3056
p.G105R	SIDM00491	Thyroid Gland Carcinoma	GDSC	PQDTPPRS	DEG_SCF_FBW7_1	0.3056
p.G105R	SIDM00291	Melanoma	GDSC	PQDTPPRS	DEG_SCF_FBW7_1	0.3056
p.G105R	SIDM01145	Gastric Carcinoma	GDSC	PQDTPPRS	DEG_SCF_FBW7_1	0.3056
p.G105R	SIDM00040	Gastric Carcinoma	GDSC	PQDTPPRS	DEG_SCF_FBW7_1	0.3056
p.G105R	SIDM00013	Melanoma	GDSC	PQDTPPRS	DEG_SCF_FBW7_1	0.3056
p.G105R	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	PQDTPPRS	DEG_SCF_FBW7_1	0.3056
p.G105R	SIDM01247	Burkitt's Lymphoma	GDSC	PQDTPPRS	DEG_SCF_FBW7_1	0.3056
p.G105R	SIDM00779	Colorectal Carcinoma	GDSC	PQDTPPRS	DEG_SCF_FBW7_1	0.3056
p.G105R	SIDM01045	Endometrial Carcinoma	GDSC	PQDTPPRS	DEG_SCF_FBW7_1	0.3056
p.G105R	SIDM00599	Osteosarcoma	GDSC	PQDTPPRS	DEG_SCF_FBW7_1	0.3056
p.G105R	SIDM00502	B-Lymphoblastic Leukemia	GDSC	PQDTPPRS	DEG_SCF_FBW7_1	0.3056
p.G105R	SIDM00240	Cervical Carcinoma	GDSC	PQDTPPRS	DEG_SCF_FBW7_1	0.3056
p.G105R	SIDM00863	Burkitt's Lymphoma	GDSC	PQDTPPRS	DEG_SCF_FBW7_1	0.3056
p.G105R	SIDM00591	Oral Cavity Carcinoma	GDSC	PQDTPPRS	DEG_SCF_FBW7_1	0.3056
p.G105R	SIDM01659	Kidney Carcinoma	GDSC	PQDTPPRS	DEG_SCF_FBW7_1	0.3056
p.G105R	SIDM00169	Head and Neck Carcinoma	GDSC	PQDTPPRS	DEG_SCF_FBW7_1	0.3056
p.G105R	SIDM01447	Glioblastoma	GDSC	PQDTPPRS	DEG_SCF_FBW7_1	0.3056
p.G105R	SIDM01454	Kidney Carcinoma	GDSC	PQDTPPRS	DEG_SCF_FBW7_1	0.3056
p.G105R	SIDM01587	Bladder Carcinoma	GDSC	PQDTPPRS	DEG_SCF_FBW7_1	0.3056
p.G105R	SIDM00016	Neuroblastoma	GDSC	PQDTPPRS	DEG_SCF_FBW7_1	0.3056
p.P94S	SIDM00221	Melanoma	GDSC	PQDTPPRS	DEG_SCF_FBW7_1	0.25
p.P94S	ACH-002388	Skin Cancer	CCLE	PQDTPPRS	DEG_SCF_FBW7_1	0.25
p.D96A	ACH-000990	Endometrial/Uterine Cancer	CCLE	PQDTPPRS	DEG_SCF_FBW7_1	0.3056
p.H114Q	ACH-001038	Bone Cancer	CCLE	PQDTPPRS	DEG_SCF_FBW7_1	0.0556
p.R102C	ESO51	oesophagus	COSMIC	PQDTPPRS	DEG_SCF_FBW7_1	0.8301

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PQDTPPRS

Degron related mutations and impact score

Drug responses associated with CREB3L3 mutations

All proteins holding degron of PQDTPPRS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68CJ9	Cyclic AMP-responsive element-binding protein 3-like protein 3	DEG_SCF_FBW7_1	97:104	PQDTPPRS	FBXW7	0.9959	More...