DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PQPTPDGE
Uniprot ID:
Q8IYW2
Source protein:
Cilia- and flagella-associated protein 46
Source gene:
CFAP46
Class:
DEG_SCF_FBW7_2
Location:
1261:1268
E3 ligase:
FBXW7
DEGRON score:
0.6408
ASA_SCORE:
89.8375
COIL:
0.9145
CONS_SCORE:
0.3553
DSS_SCORE:
0.6548
HELIX:
0.0483
FCONS_SCORE:
0.9254
RIG_SCORE:
0.6224
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with CFAP46 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PQPTPDGE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8IYW2
Cilia- and flagella-associated protein 46
DEG_SCF_FBW7_2
1261:1268
PQPTPDGE
FBXW7
0.6408
More...