DegronMD

Uniprot ID: Q14202

Source protein: Zinc finger MYM-type protein 3

Source gene: ZMYM3

Class: DEG_SCF_FBW7_1

Location: 779:785

E3 ligase: FBXW7

DEGRON score: 0.8688

ASA_SCORE: 87.9571

COIL: 0.8907

CONS_SCORE: 0.3825

DSS_SCORE: 0.8066

HELIX: 0.0409

FCONS_SCORE: 1.0741

RIG_SCORE: 0.5543

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T795S	TCGA-22-5480	LUSC	TCGA	PQTPSQT	DEG_SCF_FBW7_1	0.5
p.T795S	TCGA-CG-4437	STAD	TCGA	PQTPSQT	DEG_SCF_FBW7_1	0.5
p.S774F	TCGA-49-AARE	LUAD	TCGA	PQTPSQT	DEG_SCF_FBW7_1	0.6389
p.Q784K	TCGA-EE-A3AG	SKCM	TCGA	PQTPSQT	DEG_SCF_FBW7_1	0.5833
p.P779S	TCGA-EO-A3B0	UCEC	TCGA	PQTPSQT	DEG_SCF_FBW7_1	0.6752
p.S776P	DO225334	BRCA	ICGC	PQTPSQT	DEG_SCF_FBW7_1	0.25
p.N793K	DO228971	LICA	ICGC	PQTPSQT	DEG_SCF_FBW7_1	0.1111
p.S776F	DO218922	LUAD	ICGC	PQTPSQT	DEG_SCF_FBW7_1	0.25
p.Q786K	DO37471	SKCM	ICGC	PQTPSQT	DEG_SCF_FBW7_1	0.3056
p.P781S	DO219773	UCEC	ICGC	PQTPSQT	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14202	Zinc finger MYM-type protein 3	DEG_SCF_FBW7_1	779:785	PQTPSQT	FBXW7	0.8688	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons