DegronMD

Uniprot ID: O14771

Source protein: Zinc finger protein 213

Source gene: ZNF213

Class: DEG_APCC_DBOX_1

Location: 286:294

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7379

ASA_SCORE: 75.2889

COIL: 0.6147

CONS_SCORE: 0.4871

DSS_SCORE: 0.5747

HELIX: 0.1229

FCONS_SCORE: 0.8214

RIG_SCORE: 0.6849

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A288V	TCGA-CV-5442	HNSC	TCGA	PRAALGPVV	DEG_APCC_DBOX_1	0.5825
p.A288V	DO14678	HNSC	ICGC	PRAALGPVV	DEG_APCC_DBOX_1	0.5825
p.G291V	DO228900	LICA	ICGC	PRAALGPVV	DEG_APCC_DBOX_1	0.6421
p.A277S	DO228952	LICA	ICGC	PRAALGPVV	DEG_APCC_DBOX_1	0.0833
p.A277S	DO229022	LICA	ICGC	PRAALGPVV	DEG_APCC_DBOX_1	0.0833
p.R304L	DO229012	LICA	ICGC	PRAALGPVV	DEG_APCC_DBOX_1	0.0556
p.S282I	DO229022	LICA	ICGC	PRAALGPVV	DEG_APCC_DBOX_1	0.2222
p.E281D	DO229025	LICA	ICGC	PRAALGPVV	DEG_APCC_DBOX_1	0.1944
p.S282R	DO44806	LICA	ICGC	PRAALGPVV	DEG_APCC_DBOX_1	0.2222
p.A279V	DO229234	THCA	ICGC	PRAALGPVV	DEG_APCC_DBOX_1	0.1389
p.W280R	SIDM00683	Prostate Carcinoma	GDSC	PRAALGPVV	DEG_APCC_DBOX_1	0.1667
p.W280R	ACH-000977	lymph_node	CCLE	PRAALGPVV	DEG_APCC_DBOX_1	0.1667
p.W280R	LNCaP-Clone-FGC	prostate	COSMIC	PRAALGPVV	DEG_APCC_DBOX_1	0.1667
p.R298W	SIDM01164	Glioma	GDSC	PRAALGPVV	DEG_APCC_DBOX_1	0.2222
p.R298W	ACH-000883	Brain Cancer	CCLE	PRAALGPVV	DEG_APCC_DBOX_1	0.2222
p.R298W	SW1783	central_nervous_system	COSMIC	PRAALGPVV	DEG_APCC_DBOX_1	0.2222
p.R300Q	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PRAALGPVV	DEG_APCC_DBOX_1	0.1667
p.R300Q	ACH-001669	Leukemia	CCLE	PRAALGPVV	DEG_APCC_DBOX_1	0.1667
p.R300Q	ACH-002238	Leukemia	CCLE	PRAALGPVV	DEG_APCC_DBOX_1	0.1667
p.R300Q	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	PRAALGPVV	DEG_APCC_DBOX_1	0.1667
p.R304H	SIDM00272	Breast Carcinoma	GDSC	PRAALGPVV	DEG_APCC_DBOX_1	0.0556
p.R304H	ACH-000910	Breast Cancer	CCLE	PRAALGPVV	DEG_APCC_DBOX_1	0.0556
p.P286S	SIDM01343	Gastric Carcinoma	GDSC	PRAALGPVV	DEG_APCC_DBOX_1	0.5641
p.P286S	ACH-000764	Gastric Cancer	CCLE	PRAALGPVV	DEG_APCC_DBOX_1	0.5641
p.R285Q	ACH-001521	Skin Cancer	CCLE	PRAALGPVV	DEG_APCC_DBOX_1	0.3056
p.R285W	ACH-002372	Non-Cancerous	CCLE	PRAALGPVV	DEG_APCC_DBOX_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRAALGPVV

Degron related mutations and impact score

Drug responses associated with ZNF213 mutations

All proteins holding degron of PRAALGPVV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14771	Zinc finger protein 213	DEG_APCC_DBOX_1	286:294	PRAALGPVV	APC,CDC20,FZR1	0.7379	More...