DegronMD

Uniprot ID: Q8IVF2

Source protein: Protein AHNAK2

Source gene: AHNAK2

Class: DEG_APCC_DBOX_1

Location: 4106:4114

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8811

ASA_SCORE: 77.2778

COIL: 0.5502

CONS_SCORE: 0.2808

DSS_SCORE: 0.3974

HELIX: 0.1081

FCONS_SCORE: 0.8204

RIG_SCORE: 0.7516

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D4118N	TCGA-95-7039	LUAD	TCGA	PRAKLDGVQ	DEG_APCC_DBOX_1	0.2222
p.D4118N	DO23907	LUAD	ICGC	PRAKLDGVQ	DEG_APCC_DBOX_1	0.2222
p.A4108T	TCGA-AP-A056	UCEC	TCGA	PRAKLDGVQ	DEG_APCC_DBOX_1	0.6028
p.A4108T	DO43971	UCEC	ICGC	PRAKLDGVQ	DEG_APCC_DBOX_1	0.6028
p.L4096V	TCGA-E2-A1B1	BRCA	TCGA	PRAKLDGVQ	DEG_APCC_DBOX_1	0.0556
p.L4096V	DO3122	BRCA	ICGC	PRAKLDGVQ	DEG_APCC_DBOX_1	0.0556
p.D4111N	TCGA-GC-A3I6	BLCA	TCGA	PRAKLDGVQ	DEG_APCC_DBOX_1	0.5821
p.D4111N	DO844	BLCA	ICGC	PRAKLDGVQ	DEG_APCC_DBOX_1	0.5821
p.D4123N	TCGA-HQ-A2OE	BLCA	TCGA	PRAKLDGVQ	DEG_APCC_DBOX_1	0.0833
p.D4123N	DO540	BLCA	ICGC	PRAKLDGVQ	DEG_APCC_DBOX_1	0.0833
p.V4103I	TCGA-VQ-A8PB	STAD	TCGA	PRAKLDGVQ	DEG_APCC_DBOX_1	0.25
p.V4103I	DO51766	STAD	ICGC	PRAKLDGVQ	DEG_APCC_DBOX_1	0.25
p.A4122V	DO229453	SKCA	ICGC	PRAKLDGVQ	DEG_APCC_DBOX_1	0.1111
p.A4105T	DO229470	SKCA	ICGC	PRAKLDGVQ	DEG_APCC_DBOX_1	0.3056
p.Q4104E	SIDM02066	Colorectal Carcinoma	GDSC	PRAKLDGVQ	DEG_APCC_DBOX_1	0.2778
p.D4102V	SIDM00633	Breast Carcinoma	GDSC	PRAKLDGVQ	DEG_APCC_DBOX_1	0.2222
p.D4102V	SIDM01112	Osteosarcoma	GDSC	PRAKLDGVQ	DEG_APCC_DBOX_1	0.2222
p.D4102V	SIDM00807	Bladder Carcinoma	GDSC	PRAKLDGVQ	DEG_APCC_DBOX_1	0.2222
p.D4102V	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PRAKLDGVQ	DEG_APCC_DBOX_1	0.2222
p.Q4104R	SIDM01067	Non-Small Cell Lung Carcinoma	GDSC	PRAKLDGVQ	DEG_APCC_DBOX_1	0.2778
p.Q4104R	SIDM01746	Osteosarcoma	GDSC	PRAKLDGVQ	DEG_APCC_DBOX_1	0.2778
p.Q4104R	HCC-827	lung	COSMIC	PRAKLDGVQ	DEG_APCC_DBOX_1	0.2778
p.Q4114R	SIDM00760	Small Cell Lung Carcinoma	GDSC	PRAKLDGVQ	DEG_APCC_DBOX_1	0.6218
p.Q4114R	NCI-H1963	lung	COSMIC	PRAKLDGVQ	DEG_APCC_DBOX_1	0.6218
p.S4097P	ACH-000109	Lung Cancer	CCLE	PRAKLDGVQ	DEG_APCC_DBOX_1	0.0833
p.S4097P	H3255	lung	COSMIC	PRAKLDGVQ	DEG_APCC_DBOX_1	0.0833
p.M4099V	HOP-92	lung	COSMIC	PRAKLDGVQ	DEG_APCC_DBOX_1	0.1389
p.M4099V	NCI-H2452	pleura	COSMIC	PRAKLDGVQ	DEG_APCC_DBOX_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRAKLDGVQ

Degron related mutations and impact score

Drug responses associated with AHNAK2 mutations

All proteins holding degron of PRAKLDGVQ

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IVF2	Protein AHNAK2	DEG_APCC_DBOX_1	4106:4114	PRAKLDGVQ	APC,CDC20,FZR1	0.8811	More...