DegronMD

Uniprot ID: Q8N8Z6

Source protein: Discoidin, CUB and LCCL domain-containing protein 1

Source gene: DCBLD1

Class: DEG_APCC_DBOX_1

Location: 699:707

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9966

ASA_SCORE: 58.4

COIL: 0.7017

CONS_SCORE: 0.2485

DSS_SCORE: 0.5501

HELIX: 0.1886

FCONS_SCORE: 1.1688

RIG_SCORE: 0.7444

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S695R	DO50064	BRCA	ICGC	PRDCLTPLN	DEG_APCC_DBOX_1	0.6667
p.D694Y	DO228976	LICA	ICGC	PRDCLTPLN	DEG_APCC_DBOX_1	0.1944
p.T692R	DO232555	PBCA	ICGC	PRDCLTPLN	DEG_APCC_DBOX_1	0.1389
p.L714R	DO42033	UCEC	ICGC	PRDCLTPLN	DEG_APCC_DBOX_1	0.1389
p.L706I	DO43899	UCEC	ICGC	PRDCLTPLN	DEG_APCC_DBOX_1	0.6063

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N8Z6	Discoidin, CUB and LCCL domain-containing protein 1	DEG_APCC_DBOX_1	699:707	PRDCLTPLN	APC,CDC20,FZR1	0.9966	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons