DegronMD

Uniprot ID: Q9HCM3

Source protein: UPF0606 protein KIAA1549

Source gene: KIAA1549

Class: DEG_APCC_DBOX_1

Location: 186:194

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8723

ASA_SCORE: 100.1333

COIL: 0.8756

CONS_SCORE: 0.3056

DSS_SCORE: 0.5012

HELIX: 0.0342

FCONS_SCORE: 0.9999

RIG_SCORE: 0.7348

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V201I	TCGA-A5-A1OF	UCEC	TCGA	PREALEPML	DEG_APCC_DBOX_1	0.1389
p.V201I	DO42568	UCEC	ICGC	PREALEPML	DEG_APCC_DBOX_1	0.1389
p.P183L	TCGA-BH-A8FY	BRCA	TCGA	PREALEPML	DEG_APCC_DBOX_1	0.25
p.P183L	DO219613	BRCA	ICGC	PREALEPML	DEG_APCC_DBOX_1	0.25
p.I178T	TCGA-BR-8680	STAD	TCGA	PREALEPML	DEG_APCC_DBOX_1	0.1111
p.I178T	DO47769	STAD	ICGC	PREALEPML	DEG_APCC_DBOX_1	0.1111
p.P186H	DO233259	GACA	ICGC	PREALEPML	DEG_APCC_DBOX_1	0.6583
p.P186H	DO233760	GACA	ICGC	PREALEPML	DEG_APCC_DBOX_1	0.6583
p.P196Q	DO229037	LICA	ICGC	PREALEPML	DEG_APCC_DBOX_1	0.2778
p.Q204K	DO229009	LICA	ICGC	PREALEPML	DEG_APCC_DBOX_1	0.0556
p.E188K	DO222662	MELA	ICGC	PREALEPML	DEG_APCC_DBOX_1	0.591
p.P192H	ACH-000954	Endometrial/Uterine Cancer	CCLE	PREALEPML	DEG_APCC_DBOX_1	0.6583

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCM3	UPF0606 protein KIAA1549	DEG_APCC_DBOX_1	186:194	PREALEPML	APC,CDC20,FZR1	0.8723	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons