DegronMD

Uniprot ID: Q7Z553

Source protein: MAM domain-containing glycosylphosphatidylinositol anchor protein 2

Source gene: MDGA2

Class: DEG_APCC_DBOX_1

Location: 527:535

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5385

ASA_SCORE: 56.1444

COIL: 0.1533

CONS_SCORE: 0.8745

DSS_SCORE: 0.1682

HELIX: 0.0039

FCONS_SCORE: 0.9277

RIG_SCORE: 0.8753

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K539N	TCGA-55-8506	LUAD	TCGA	PREALVQLI	DEG_APCC_DBOX_1	0.2222
p.K539N	DO45390	LUAD	ICGC	PREALVQLI	DEG_APCC_DBOX_1	0.2222
p.T529A	TCGA-56-6545	LUSC	TCGA	PREALVQLI	DEG_APCC_DBOX_1	0.7139
p.T529A	DO26532	LUSC	ICGC	PREALVQLI	DEG_APCC_DBOX_1	0.7139
p.Q517K	TCGA-68-7755	LUSC	TCGA	PREALVQLI	DEG_APCC_DBOX_1	0.0556
p.Q517K	DO26512	LUSC	ICGC	PREALVQLI	DEG_APCC_DBOX_1	0.0556
p.Q517L	TCGA-73-4668	LUAD	TCGA	PREALVQLI	DEG_APCC_DBOX_1	0.0556
p.Q517L	DO23961	LUAD	ICGC	PREALVQLI	DEG_APCC_DBOX_1	0.0556
p.P521Q	TCGA-AA-3811	COAD	TCGA	PREALVQLI	DEG_APCC_DBOX_1	0.1667
p.P521Q	DO7962	COAD	ICGC	PREALVQLI	DEG_APCC_DBOX_1	0.1667
p.P542L	TCGA-BK-A6W3	UCEC	TCGA	PREALVQLI	DEG_APCC_DBOX_1	0.1389
p.P542L	DO50076	UCEC	ICGC	PREALVQLI	DEG_APCC_DBOX_1	0.1389
p.V536L	TCGA-CV-6936	HNSC	TCGA	PREALVQLI	DEG_APCC_DBOX_1	0.3056
p.V536L	DO14210	HNSC	ICGC	PREALVQLI	DEG_APCC_DBOX_1	0.3056
p.G527E	TCGA-D3-A1Q8	SKCM	TCGA	PREALVQLI	DEG_APCC_DBOX_1	0.7199
p.G527E	DO37446	SKCM	ICGC	PREALVQLI	DEG_APCC_DBOX_1	0.7199
p.S520L	TCGA-EE-A3J5	SKCM	TCGA	PREALVQLI	DEG_APCC_DBOX_1	0.1389
p.S520L	DO47331	SKCM	ICGC	PREALVQLI	DEG_APCC_DBOX_1	0.1389
p.G538V	TCGA-EO-A1Y5	UCEC	TCGA	PREALVQLI	DEG_APCC_DBOX_1	0.25
p.G538V	DO42073	UCEC	ICGC	PREALVQLI	DEG_APCC_DBOX_1	0.25
p.G538V	NCI-H630	large_intestine	COSMIC	PREALVQLI	DEG_APCC_DBOX_1	0.25
p.Q531E	DO44384	CESC	ICGC	PREALVQLI	DEG_APCC_DBOX_1	0.6744
p.Q531E	DO234355	ESAD	ICGC	PREALVQLI	DEG_APCC_DBOX_1	0.6744
p.V525M	DO51991	CLLE	ICGC	PREALVQLI	DEG_APCC_DBOX_1	0.2778
p.V525M	SIDM00417	Plasma Cell Myeloma	GDSC	PREALVQLI	DEG_APCC_DBOX_1	0.2778
p.V525M	ACH-000626	Myeloma	CCLE	PREALVQLI	DEG_APCC_DBOX_1	0.2778
p.V525M	U-266	haematopoietic_and_lymphoid_tissue	COSMIC	PREALVQLI	DEG_APCC_DBOX_1	0.2778
p.D528G	DO227802	COCA	ICGC	PREALVQLI	DEG_APCC_DBOX_1	0.7198
p.E518D	DO233181	GACA	ICGC	PREALVQLI	DEG_APCC_DBOX_1	0.0833
p.F523C	DO233266	GACA	ICGC	PREALVQLI	DEG_APCC_DBOX_1	0.2222
p.T544A	DO10880	GBM	ICGC	PREALVQLI	DEG_APCC_DBOX_1	0.0833
p.P539R	DO15591	HNSC	ICGC	PREALVQLI	DEG_APCC_DBOX_1	0.2222
p.D528E	DO228985	LICA	ICGC	PREALVQLI	DEG_APCC_DBOX_1	0.6758
p.Q535K	DO229035	LICA	ICGC	PREALVQLI	DEG_APCC_DBOX_1	0.6944
p.P542T	DO50931	LICA	ICGC	PREALVQLI	DEG_APCC_DBOX_1	0.1389
p.N521K	DO23204	LINC	ICGC	PREALVQLI	DEG_APCC_DBOX_1	0.1667
p.N536S	DO45373	LUAD	ICGC	PREALVQLI	DEG_APCC_DBOX_1	0.3056
p.S543R	DO224551	LUSC	ICGC	PREALVQLI	DEG_APCC_DBOX_1	0.1111
p.T517N	DO45490	LUSC	ICGC	PREALVQLI	DEG_APCC_DBOX_1	0.0556
p.H518Y	DO220882	MELA	ICGC	PREALVQLI	DEG_APCC_DBOX_1	0.0833
p.H518Y	DO219450	SKCM	ICGC	PREALVQLI	DEG_APCC_DBOX_1	0.0833
p.I526V	DO232064	ORCA	ICGC	PREALVQLI	DEG_APCC_DBOX_1	0.3056
p.T544R	DO35196	PACA	ICGC	PREALVQLI	DEG_APCC_DBOX_1	0.0833
p.Q533H	DO229073	PRAD	ICGC	PREALVQLI	DEG_APCC_DBOX_1	0.647
p.H518N	DO36556	READ	ICGC	PREALVQLI	DEG_APCC_DBOX_1	0.0833
p.T517P	DO219881	SKCA	ICGC	PREALVQLI	DEG_APCC_DBOX_1	0.0556
p.T517P	DO229499	SKCA	ICGC	PREALVQLI	DEG_APCC_DBOX_1	0.0556
p.T517P	DO218878	SKCA	ICGC	PREALVQLI	DEG_APCC_DBOX_1	0.0556
p.T517P	DO218842	SKCA	ICGC	PREALVQLI	DEG_APCC_DBOX_1	0.0556
p.G524V	DO43186	UCEC	ICGC	PREALVQLI	DEG_APCC_DBOX_1	0.25
p.A530S	SIDM00781	Colorectal Carcinoma	GDSC	PREALVQLI	DEG_APCC_DBOX_1	0.6477
p.A530S	SIDM00780	Colorectal Carcinoma	GDSC	PREALVQLI	DEG_APCC_DBOX_1	0.6477
p.A530S	ACH-000967	Colon/Colorectal Cancer	CCLE	PREALVQLI	DEG_APCC_DBOX_1	0.6477
p.A530S	ACH-001199	Colon/Colorectal Cancer	CCLE	PREALVQLI	DEG_APCC_DBOX_1	0.6477
p.A530S	SNU-C2B	large_intestine	COSMIC	PREALVQLI	DEG_APCC_DBOX_1	0.6477
p.I535M	SIDM01118	Small Cell Lung Carcinoma	GDSC	PREALVQLI	DEG_APCC_DBOX_1	0.6507
p.I535M	ACH-002175	Lung Cancer	CCLE	PREALVQLI	DEG_APCC_DBOX_1	0.6507
p.I535M	NCI-H740	lung	COSMIC	PREALVQLI	DEG_APCC_DBOX_1	0.6507
p.V536I	SIDM00429	B-Lymphoblastic Leukemia	GDSC	PREALVQLI	DEG_APCC_DBOX_1	0.3056
p.V536I	ACH-000938	Leukemia	CCLE	PREALVQLI	DEG_APCC_DBOX_1	0.3056
p.V536I	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	PREALVQLI	DEG_APCC_DBOX_1	0.3056
p.P539A	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	PREALVQLI	DEG_APCC_DBOX_1	0.2222
p.P539A	TE-9	oesophagus	COSMIC	PREALVQLI	DEG_APCC_DBOX_1	0.2222
p.A541T	SIDM00740	Squamous Cell Lung Carcinoma	GDSC	PREALVQLI	DEG_APCC_DBOX_1	0.1667
p.A541T	ACH-000747	Lung Cancer	CCLE	PREALVQLI	DEG_APCC_DBOX_1	0.1667
p.A541T	NCI-H1703	lung	COSMIC	PREALVQLI	DEG_APCC_DBOX_1	0.1667
p.S518R	SIDM01018	Hodgkin's Lymphoma	GDSC	PREALVQLI	DEG_APCC_DBOX_1	0.0833
p.S518R	ACH-000815	Lymphoma	CCLE	PREALVQLI	DEG_APCC_DBOX_1	0.0833
p.S518R	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	PREALVQLI	DEG_APCC_DBOX_1	0.0833
p.Q537R	ACH-001611	Brain Cancer	CCLE	PREALVQLI	DEG_APCC_DBOX_1	0.2778
p.E518Q	OE21	oesophagus	COSMIC	PREALVQLI	DEG_APCC_DBOX_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PREALVQLI

Degron related mutations and impact score

Drug responses associated with MDGA2 mutations

All proteins holding degron of PREALVQLI

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z553	MAM domain-containing glycosylphosphatidylinositol anchor protein 2	DEG_APCC_DBOX_1	527:535	PREALVQLI	APC,CDC20,FZR1	0.5385	More...