DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PREKTPPK
Uniprot ID:
O60765
Source protein:
Zinc finger protein 354A
Source gene:
ZNF354A
Class:
DEG_SCF_SKP2-CKS1_1
Location:
181:188
E3 ligase:
SKP2,CSK1
DEGRON score:
0.8839
ASA_SCORE:
101.2875
COIL:
0.8396
CONS_SCORE:
0.7009
DSS_SCORE:
0.5531
HELIX:
0.0209
FCONS_SCORE:
1.2256
RIG_SCORE:
0.6999
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P181L
TCGA-EE-A3J8
SKCM
TCGA
PREKTPPK
DEG_SCF_SKP2-CKS1_1
0.6471
p.P181L
DO47276
SKCM
ICGC
PREKTPPK
DEG_SCF_SKP2-CKS1_1
0.6471
p.P187Q
DO229019
LICA
ICGC
PREKTPPK
DEG_SCF_SKP2-CKS1_1
0.5924
p.E183D
SIDM01254
Burkitt's Lymphoma
GDSC
PREKTPPK
DEG_SCF_SKP2-CKS1_1
0.5647
p.E183D
ACH-000707
Lymphoma
CCLE
PREKTPPK
DEG_SCF_SKP2-CKS1_1
0.5647
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Drug responses associated with ZNF354A mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of PREKTPPK
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O60765
Zinc finger protein 354A
DEG_SCF_SKP2-CKS1_1
181:188
PREKTPPK
SKP2,CSK1
0.8839
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