DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PREKTPPK
Uniprot ID:
O60765
Source protein:
Zinc finger protein 354A
Source gene:
ZNF354A
Class:
DEG_SCF_SKP2-CKS1_1
Location:
181:188
E3 ligase:
SKP2,CSK1
DEGRON score:
0.8839
ASA_SCORE:
101.2875
COIL:
0.8396
CONS_SCORE:
0.7009
DSS_SCORE:
0.5531
HELIX:
0.0209
FCONS_SCORE:
1.2256
RIG_SCORE:
0.6999
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P181L
TCGA-EE-A3J8
SKCM
TCGA
PREKTPPK
DEG_SCF_SKP2-CKS1_1
0.6471
p.P181L
DO47276
SKCM
ICGC
PREKTPPK
DEG_SCF_SKP2-CKS1_1
0.6471
p.P187Q
DO229019
LICA
ICGC
PREKTPPK
DEG_SCF_SKP2-CKS1_1
0.5924
p.E183D
SIDM01254
Burkitt's Lymphoma
GDSC
PREKTPPK
DEG_SCF_SKP2-CKS1_1
0.5647
p.E183D
ACH-000707
Lymphoma
CCLE
PREKTPPK
DEG_SCF_SKP2-CKS1_1
0.5647
Drug responses associated with ZNF354A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PREKTPPK
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O60765
Zinc finger protein 354A
DEG_SCF_SKP2-CKS1_1
181:188
PREKTPPK
SKP2,CSK1
0.8839
More...