DegronMD

Uniprot ID: P13010

Source protein: X-ray repair cross-complementing protein 5

Source gene: XRCC5

Class: DEG_APCC_DBOX_1

Location: 501:509

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8996

ASA_SCORE: 85.0556

COIL: 0.937

CONS_SCORE: 0.3882

DSS_SCORE: 0.3067

HELIX: 0.0431

FCONS_SCORE: 0.9107

RIG_SCORE: 0.6963

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R502W	TCGA-AD-6889	COAD	TCGA	PREPLPPIQ	DEG_APCC_DBOX_1	0.8634
p.R502W	DO8463	COAD	ICGC	PREPLPPIQ	DEG_APCC_DBOX_1	0.8634
p.R502Q	TCGA-AZ-4615	COAD	TCGA	PREPLPPIQ	DEG_APCC_DBOX_1	0.7329
p.R502Q	DO7977	COAD	ICGC	PREPLPPIQ	DEG_APCC_DBOX_1	0.7329
p.C493Y	TCGA-D1-A2G0	UCEC	TCGA	PREPLPPIQ	DEG_APCC_DBOX_1	0.1111
p.C493Y	DO43049	UCEC	ICGC	PREPLPPIQ	DEG_APCC_DBOX_1	0.1111
p.E503Q	DO218173	BRCA	ICGC	PREPLPPIQ	DEG_APCC_DBOX_1	0.5633
p.Q509H	DO229009	LICA	ICGC	PREPLPPIQ	DEG_APCC_DBOX_1	0.647
p.N517S	SIDM00183	Small Cell Lung Carcinoma	GDSC	PREPLPPIQ	DEG_APCC_DBOX_1	0.1111
p.N517S	SIDM00734	Non-Small Cell Lung Carcinoma	GDSC	PREPLPPIQ	DEG_APCC_DBOX_1	0.1111
p.N517S	SIDM01680	Non-Cancerous	GDSC	PREPLPPIQ	DEG_APCC_DBOX_1	0.1111
p.N517S	SIDM01648	Non-Cancerous	GDSC	PREPLPPIQ	DEG_APCC_DBOX_1	0.1111
p.I508V	SIDM00488	Colorectal Carcinoma	GDSC	PREPLPPIQ	DEG_APCC_DBOX_1	0.5965
p.I508V	SIDM01727	Chronic Myelogenous Leukemia	GDSC	PREPLPPIQ	DEG_APCC_DBOX_1	0.5965
p.I508V	SIDM01622	Breast Carcinoma	GDSC	PREPLPPIQ	DEG_APCC_DBOX_1	0.5965
p.I508V	SIDM01454	Kidney Carcinoma	GDSC	PREPLPPIQ	DEG_APCC_DBOX_1	0.5965
p.R497S	SIDM00150	Colorectal Carcinoma	GDSC	PREPLPPIQ	DEG_APCC_DBOX_1	0.2222
p.R497S	ACH-000969	Colon/Colorectal Cancer	CCLE	PREPLPPIQ	DEG_APCC_DBOX_1	0.2222
p.R497S	KM12	large_intestine	COSMIC	PREPLPPIQ	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13010	X-ray repair cross-complementing protein 5	DEG_APCC_DBOX_1	501:509	PREPLPPIQ	APC,CDC20,FZR1	0.8996	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons