DegronMD

Uniprot ID: P19525

Source protein: Interferon-induced, double-stranded RNA-activated protein kinase

Source gene: EIF2AK2

Class: DEG_APCC_DBOX_1

Location: 245:253

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9973

ASA_SCORE: 95.3333

COIL: 0.7831

CONS_SCORE: 0.4128

DSS_SCORE: 0.419

HELIX: 0.1804

FCONS_SCORE: 1.0344

RIG_SCORE: 0.7513

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N235I	TCGA-CK-4951	COAD	TCGA	PRFDLPDMK	DEG_APCC_DBOX_1	0.0556
p.N235I	DO10582	COAD	ICGC	PRFDLPDMK	DEG_APCC_DBOX_1	0.0556
p.P245L	TCGA-EE-A180	SKCM	TCGA	PRFDLPDMK	DEG_APCC_DBOX_1	0.6471
p.P245L	DO47537	SKCM	ICGC	PRFDLPDMK	DEG_APCC_DBOX_1	0.6471
p.M252I	TCGA-FD-A62P	BLCA	TCGA	PRFDLPDMK	DEG_APCC_DBOX_1	0.6507
p.M252I	DO44054	BLCA	ICGC	PRFDLPDMK	DEG_APCC_DBOX_1	0.6507
p.F263S	TCGA-HJ-7597	STAD	TCGA	PRFDLPDMK	DEG_APCC_DBOX_1	0.0556
p.F263S	DO38195	STAD	ICGC	PRFDLPDMK	DEG_APCC_DBOX_1	0.0556
p.E254K	TCGA-RD-A8N6	STAD	TCGA	PRFDLPDMK	DEG_APCC_DBOX_1	0.3056
p.E254K	DO50140	STAD	ICGC	PRFDLPDMK	DEG_APCC_DBOX_1	0.3056
p.R262K	DO222634	ESCA	ICGC	PRFDLPDMK	DEG_APCC_DBOX_1	0.0833
p.D260E	DO228976	LICA	ICGC	PRFDLPDMK	DEG_APCC_DBOX_1	0.1389
p.P250T	DO229019	LICA	ICGC	PRFDLPDMK	DEG_APCC_DBOX_1	0.5919
p.L243S	DO231646	LINC	ICGC	PRFDLPDMK	DEG_APCC_DBOX_1	0.2778
p.V259A	SIDM00487	Colorectal Carcinoma	GDSC	PRFDLPDMK	DEG_APCC_DBOX_1	0.1667
p.V259A	ACH-000963	Colon/Colorectal Cancer	CCLE	PRFDLPDMK	DEG_APCC_DBOX_1	0.1667
p.V259A	CCK-81	large_intestine	COSMIC	PRFDLPDMK	DEG_APCC_DBOX_1	0.1667
p.V259G	SIDM01085	Bladder Carcinoma	GDSC	PRFDLPDMK	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P19525	Interferon-induced, double-stranded RNA-activated protein kinase	DEG_APCC_DBOX_1	245:253	PRFDLPDMK	APC,CDC20,FZR1	0.9973	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons