DegronMD

Uniprot ID: Q9HCU0

Source protein: Endosialin

Source gene: CD248

Class: DEG_APCC_DBOX_1

Location: 743:751

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.92

ASA_SCORE: 78.7889

COIL: 0.8046

CONS_SCORE: 0.6214

DSS_SCORE: 0.6664

HELIX: 0.0747

FCONS_SCORE: 1.142

RIG_SCORE: 0.6688

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S734N	TCGA-AF-2691	READ	TCGA	PRGSLTGVQ	DEG_APCC_DBOX_1	0.0833
p.S734N	DO36969	READ	ICGC	PRGSLTGVQ	DEG_APCC_DBOX_1	0.0833
p.V757L	TCGA-EW-A1PB	BRCA	TCGA	PRGSLTGVQ	DEG_APCC_DBOX_1	0.1667
p.V757L	DO4695	BRCA	ICGC	PRGSLTGVQ	DEG_APCC_DBOX_1	0.1667
p.T748P	DO50511	BOCA	ICGC	PRGSLTGVQ	DEG_APCC_DBOX_1	0.5919
p.S736R	DO229019	LICA	ICGC	PRGSLTGVQ	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCU0	Endosialin	DEG_APCC_DBOX_1	743:751	PRGSLTGVQ	APC,CDC20,FZR1	0.92	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons