DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PRGVLEGLR
Uniprot ID:
Q86UD0
Source protein:
Suppressor APC domain-containing protein 2
Source gene:
SAPCD2
Class:
DEG_APCC_DBOX_1
Location:
65:73
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9909
ASA_SCORE:
52.2778
COIL:
0.2251
CONS_SCORE:
0.7738
DSS_SCORE:
0.2907
HELIX:
0.7636
FCONS_SCORE:
1.167
RIG_SCORE:
0.7873
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R66G
SIDM01618
B-Lymphoblastic Leukemia
GDSC
PRGVLEGLR
DEG_APCC_DBOX_1
0.7568
Drug responses associated with SAPCD2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PRGVLEGLR
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q86UD0
Suppressor APC domain-containing protein 2
DEG_APCC_DBOX_1
65:73
PRGVLEGLR
APC,CDC20,FZR1
0.9909
More...