DegronMD

Uniprot ID: Q86UD0

Source protein: Suppressor APC domain-containing protein 2

Source gene: SAPCD2

Class: DEG_APCC_DBOX_1

Location: 65:73

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9909

ASA_SCORE: 52.2778

COIL: 0.2251

CONS_SCORE: 0.7738

DSS_SCORE: 0.2907

HELIX: 0.7636

FCONS_SCORE: 1.167

RIG_SCORE: 0.7873

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R66G	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PRGVLEGLR	DEG_APCC_DBOX_1	0.7568

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UD0	Suppressor APC domain-containing protein 2	DEG_APCC_DBOX_1	65:73	PRGVLEGLR	APC,CDC20,FZR1	0.9909	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons