DegronMD

Uniprot ID: Q9NZJ0

Source protein: Denticleless protein homolog

Source gene: DTL

Class: DEG_APCC_DBOX_1

Location: 527:535

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9534

ASA_SCORE: 64.3

COIL: 0.5064

CONS_SCORE: 0.401

DSS_SCORE: 0.5828

HELIX: 0.1021

FCONS_SCORE: 1.0178

RIG_SCORE: 0.7108

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R528I	TCGA-B5-A0JY	UCEC	TCGA	PRKALIPVS	DEG_APCC_DBOX_1	0.8102
p.P527L	TCGA-BR-4184	STAD	TCGA	PRKALIPVS	DEG_APCC_DBOX_1	0.6471
p.P527L	TCGA-OD-A75X	SKCM	TCGA	PRKALIPVS	DEG_APCC_DBOX_1	0.6471
p.P533H	TCGA-BS-A0UL	UCEC	TCGA	PRKALIPVS	DEG_APCC_DBOX_1	0.6583
p.P527S	TCGA-OD-A75X	SKCM	TCGA	PRKALIPVS	DEG_APCC_DBOX_1	0.5641
p.V521L	DO229037	LICA	ICGC	PRKALIPVS	DEG_APCC_DBOX_1	0.1667
p.H543R	DO36556	READ	ICGC	PRKALIPVS	DEG_APCC_DBOX_1	0.1111
p.Q540P	SIDM00047	Non-Small Cell Lung Carcinoma	GDSC	PRKALIPVS	DEG_APCC_DBOX_1	0.1944
p.Q540P	ACH-002102	Lung Cancer	CCLE	PRKALIPVS	DEG_APCC_DBOX_1	0.1944
p.Q540P	EMC-BAC-2	lung	COSMIC	PRKALIPVS	DEG_APCC_DBOX_1	0.1944
p.K522Q	Hep_3B2_1-7	NS	COSMIC	PRKALIPVS	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZJ0	Denticleless protein homolog	DEG_APCC_DBOX_1	527:535	PRKALIPVS	APC,CDC20,FZR1	0.9534	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons