DegronMD

Uniprot ID: Q9Y2T7

Source protein: Y-box-binding protein 2

Source gene: YBX2

Class: DEG_APCC_DBOX_1

Location: 131:139

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6931

ASA_SCORE: 67.9333

COIL: 0.5644

CONS_SCORE: 0.6319

DSS_SCORE: 0.4238

HELIX: 0.0408

FCONS_SCORE: 0.8446

RIG_SCORE: 0.7576

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E145A	TCGA-2W-A8YY	CESC	TCGA	PRKFLRSVG	DEG_APCC_DBOX_1	0.1667
p.E145A	DO223732	CESC	ICGC	PRKFLRSVG	DEG_APCC_DBOX_1	0.1667
p.V138A	TCGA-41-2575	GBM	TCGA	PRKFLRSVG	DEG_APCC_DBOX_1	0.6936
p.V138A	DO10874	GBM	ICGC	PRKFLRSVG	DEG_APCC_DBOX_1	0.6936
p.S137C	TCGA-86-7714	LUAD	TCGA	PRKFLRSVG	DEG_APCC_DBOX_1	0.7541
p.S137C	DO24870	LUAD	ICGC	PRKFLRSVG	DEG_APCC_DBOX_1	0.7541
p.R136H	TCGA-AA-A010	COAD	TCGA	PRKFLRSVG	DEG_APCC_DBOX_1	0.7133
p.R136H	ACH-001518	Endometrial/Uterine Cancer	CCLE	PRKFLRSVG	DEG_APCC_DBOX_1	0.7133
p.K133T	TCGA-BK-A6W3	UCEC	TCGA	PRKFLRSVG	DEG_APCC_DBOX_1	0.6195
p.K133T	DO50076	UCEC	ICGC	PRKFLRSVG	DEG_APCC_DBOX_1	0.6195
p.P131H	TCGA-EC-A24G	UCEC	TCGA	PRKFLRSVG	DEG_APCC_DBOX_1	0.6583
p.P131H	DO40996	UCEC	ICGC	PRKFLRSVG	DEG_APCC_DBOX_1	0.6583
p.Q123H	TCGA-IB-7651	PAAD	TCGA	PRKFLRSVG	DEG_APCC_DBOX_1	0.1111
p.R136C	DO233272	GACA	ICGC	PRKFLRSVG	DEG_APCC_DBOX_1	0.719
p.R128K	DO228974	LICA	ICGC	PRKFLRSVG	DEG_APCC_DBOX_1	0.25
p.N130K	DO229041	LICA	ICGC	PRKFLRSVG	DEG_APCC_DBOX_1	0.3056
p.V121I	SIDM00773	Non-Cancerous	GDSC	PRKFLRSVG	DEG_APCC_DBOX_1	0.0556
p.V121I	ACH-002381	Non-Cancerous	CCLE	PRKFLRSVG	DEG_APCC_DBOX_1	0.0556
p.V149M	SIDM00217	Colorectal Carcinoma	GDSC	PRKFLRSVG	DEG_APCC_DBOX_1	0.0556
p.V149M	ACH-000999	Colon/Colorectal Cancer	CCLE	PRKFLRSVG	DEG_APCC_DBOX_1	0.0556
p.V149M	SNU-1040	large_intestine	COSMIC	PRKFLRSVG	DEG_APCC_DBOX_1	0.0556
p.A125D	SIDM01150	Non-Small Cell Lung Carcinoma	GDSC	PRKFLRSVG	DEG_APCC_DBOX_1	0.1667
p.A125D	ACH-000416	Lung Cancer	CCLE	PRKFLRSVG	DEG_APCC_DBOX_1	0.1667
p.A125D	NCI-H838	lung	COSMIC	PRKFLRSVG	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2T7	Y-box-binding protein 2	DEG_APCC_DBOX_1	131:139	PRKFLRSVG	APC,CDC20,FZR1	0.6931	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRKFLRSVG

Degron related mutations and impact score

Drug responses associated with YBX2 mutations

All proteins holding degron of PRKFLRSVG