DegronMD

Uniprot ID: P09564

Source protein: T-cell antigen CD7

Source gene: CD7

Class: DEG_APCC_DBOX_1

Location: 5:13

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7477

ASA_SCORE: 68.4111

COIL: 0.184

CONS_SCORE: 0.58

DSS_SCORE: 0.1339

HELIX: 0.815

FCONS_SCORE: 1.3479

RIG_SCORE: 0.884

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L14V	TCGA-AX-A2IO	UCEC	TCGA	PRLLLLPLL	DEG_APCC_DBOX_1	0.3056
p.G3R	TCGA-DD-AADW	LIHC	TCGA	PRLLLLPLL	DEG_APCC_DBOX_1	0.2778
p.G3R	DO52249	LIHC	ICGC	PRLLLLPLL	DEG_APCC_DBOX_1	0.2778
p.P5L	TCGA-GN-A4U3	SKCM	TCGA	PRLLLLPLL	DEG_APCC_DBOX_1	0.6471
p.R3C	DO9346	COAD	ICGC	PRLLLLPLL	DEG_APCC_DBOX_1	0.2778
p.R3H	DO12328	GBM	ICGC	PRLLLLPLL	DEG_APCC_DBOX_1	0.2778
p.Y23N	DO220895	MELA	ICGC	PRLLLLPLL	DEG_APCC_DBOX_1	0.0556
p.S7L	DO50422	PRAD	ICGC	PRLLLLPLL	DEG_APCC_DBOX_1	0.7667
p.L7P	DO229257	THCA	ICGC	PRLLLLPLL	DEG_APCC_DBOX_1	0.6471
p.G19C	SIDM00541	Colorectal Carcinoma	GDSC	PRLLLLPLL	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P09564	T-cell antigen CD7	DEG_APCC_DBOX_1	5:13	PRLLLLPLL	APC,CDC20,FZR1	0.7477	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons