DegronMD

Uniprot ID: O95785

Source protein: Protein Wiz

Source gene: WIZ

Class: DEG_APCC_DBOX_1

Location: 946:954

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9919

ASA_SCORE: 79.9

COIL: 0.8618

CONS_SCORE: 0.6635

DSS_SCORE: 0.3693

HELIX: 0.0762

FCONS_SCORE: 1.103

RIG_SCORE: 0.7224

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R947Q	ACH-000942	Leukemia	CCLE	PRPGLLSLA	DEG_APCC_DBOX_1	0.7329
p.D949G	ACH-000984	Endometrial/Uterine Cancer	CCLE	PRPGLLSLA	DEG_APCC_DBOX_1	0.7198
p.A963V	ACH-001670	Brain Cancer	CCLE	PRPGLLSLA	DEG_APCC_DBOX_1	0.0833
p.A963V	TASK1	bone	COSMIC	PRPGLLSLA	DEG_APCC_DBOX_1	0.0833
p.A960V	TASK1	bone	COSMIC	PRPGLLSLA	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95785	Protein Wiz	DEG_APCC_DBOX_1	946:954	PRPGLLSLA	APC,CDC20,FZR1	0.9919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons