DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PRPGLRRLA
Uniprot ID:
P0CW18
Source protein:
Serine protease 56
Source gene:
PRSS56
Class:
DEG_APCC_DBOX_1
Location:
417:425
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.97
ASA_SCORE:
73.5778
COIL:
0.8313
CONS_SCORE:
0.3534
DSS_SCORE:
0.2886
HELIX:
0.0664
FCONS_SCORE:
1.0674
RIG_SCORE:
0.7159
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G417V
DO233903
GACA
ICGC
PRPGLRRLA
DEG_APCC_DBOX_1
0.7532
p.N411K
DO228520
LICA
ICGC
PRPGLRRLA
DEG_APCC_DBOX_1
0.1667
Drug responses associated with PRSS56 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PRPGLRRLA
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P0CW18
Serine protease 56
DEG_APCC_DBOX_1
417:425
PRPGLRRLA
APC,CDC20,FZR1
0.97
More...