DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PRPQLSFLG
Uniprot ID:
P0DJG4
Source protein:
Testicular haploid expressed gene protein-like
Source gene:
THEGL
Class:
DEG_APCC_DBOX_1
Location:
156:164
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.79
ASA_SCORE:
71.4
COIL:
0.6888
CONS_SCORE:
0.2912
DSS_SCORE:
0.3603
HELIX:
0.1456
FCONS_SCORE:
1.0211
RIG_SCORE:
0.719
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R157W
DO45299
LIRI
ICGC
PRPQLSFLG
DEG_APCC_DBOX_1
0.8634
Drug responses associated with THEGL mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PRPQLSFLG
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P0DJG4
Testicular haploid expressed gene protein-like
DEG_APCC_DBOX_1
156:164
PRPQLSFLG
APC,CDC20,FZR1
0.79
More...