DegronMD

Uniprot ID: C9JN71

Source protein: Zinc finger protein 878

Source gene: ZNF878

Class: DEG_APCC_DBOX_1

Location: 59:67

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.743

ASA_SCORE: 108.6

COIL: 0.688

CONS_SCORE: 0.3133

DSS_SCORE: 0.5193

HELIX: 0.1261

FCONS_SCORE: 0.8279

RIG_SCORE: 0.7435

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R65I	TCGA-EO-A3AY	UCEC	TCGA	PRRNLRRLI	DEG_APCC_DBOX_1	0.6991
p.R65I	DO232224	PBCA	ICGC	PRRNLRRLI	DEG_APCC_DBOX_1	0.6991
p.R65I	DO43202	UCEC	ICGC	PRRNLRRLI	DEG_APCC_DBOX_1	0.6991
p.I67V	TCGA-UY-A9PD	BLCA	TCGA	PRRNLRRLI	DEG_APCC_DBOX_1	0.5965
p.N58I	DO234363	ESAD	ICGC	PRRNLRRLI	DEG_APCC_DBOX_1	0.3056
p.P59T	DO223138	ESCA	ICGC	PRRNLRRLI	DEG_APCC_DBOX_1	0.5919
p.A57V	DO41235	UCEC	ICGC	PRRNLRRLI	DEG_APCC_DBOX_1	0.2778
p.E55K	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PRRNLRRLI	DEG_APCC_DBOX_1	0.2222
p.E55K	ACH-000983	Leukemia	CCLE	PRRNLRRLI	DEG_APCC_DBOX_1	0.2222
p.E55K	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	PRRNLRRLI	DEG_APCC_DBOX_1	0.2222
p.R61I	SIDM01611	Endometrial Carcinoma	GDSC	PRRNLRRLI	DEG_APCC_DBOX_1	0.6991
p.R61I	ACH-000996	Endometrial/Uterine Cancer	CCLE	PRRNLRRLI	DEG_APCC_DBOX_1	0.6991
p.L66R	SIDM01588	Endometrial Carcinoma	GDSC	PRRNLRRLI	DEG_APCC_DBOX_1	0.8428

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
C9JN71	Zinc finger protein 878	DEG_APCC_DBOX_1	59:67	PRRNLRRLI	APC,CDC20,FZR1	0.743	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons