DegronMD

Uniprot ID: Q13043

Source protein: Serine/threonine-protein kinase 4

Source gene: STK4

Class: DEG_APCC_DBOX_1

Location: 10:18

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5236

ASA_SCORE: 105.0222

COIL: 0.6783

CONS_SCORE: 0.3286

DSS_SCORE: 0.6043

HELIX: 0.2844

FCONS_SCORE: 1.0311

RIG_SCORE: 0.7215

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K16R	TCGA-CF-A47X	BLCA	TCGA	PRRQLKKLD	DEG_APCC_DBOX_1	0.6126
p.K16R	DO44042	BLCA	ICGC	PRRQLKKLD	DEG_APCC_DBOX_1	0.6126
p.L6P	DO230335	COCA	ICGC	PRRQLKKLD	DEG_APCC_DBOX_1	0.2222
p.E28K	DO234350	ESAD	ICGC	PRRQLKKLD	DEG_APCC_DBOX_1	0.0556
p.L17S	DO229208	THCA	ICGC	PRRQLKKLD	DEG_APCC_DBOX_1	0.7667
p.S21R	SIDM00217	Colorectal Carcinoma	GDSC	PRRQLKKLD	DEG_APCC_DBOX_1	0.6944
p.S21R	ACH-000999	Colon/Colorectal Cancer	CCLE	PRRQLKKLD	DEG_APCC_DBOX_1	0.6944
p.S21R	SNU-1040	large_intestine	COSMIC	PRRQLKKLD	DEG_APCC_DBOX_1	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13043	Serine/threonine-protein kinase 4	DEG_APCC_DBOX_1	10:18	PRRQLKKLD	APC,CDC20,FZR1	0.5236	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons