DegronMD

Uniprot ID: Q9NTX9

Source protein: Protein FAM217B

Source gene: FAM217B

Class: DEG_APCC_DBOX_1

Location: 33:41

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5201

ASA_SCORE: 89.0333

COIL: 0.8692

CONS_SCORE: 0.4578

DSS_SCORE: 0.7411

HELIX: 0.1078

FCONS_SCORE: 0.8899

RIG_SCORE: 0.5979

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P27S	TCGA-23-1117	OV	TCGA	PRSSLTAVT	DEG_APCC_DBOX_1	0.1667
p.P27S	DO30830	OV	ICGC	PRSSLTAVT	DEG_APCC_DBOX_1	0.1667
p.K47R	TCGA-23-1117	OV	TCGA	PRSSLTAVT	DEG_APCC_DBOX_1	0.2778
p.K47R	DO30830	OV	ICGC	PRSSLTAVT	DEG_APCC_DBOX_1	0.2778
p.V26L	TCGA-39-5011	LUSC	TCGA	PRSSLTAVT	DEG_APCC_DBOX_1	0.1389
p.V26L	DO27532	LUSC	ICGC	PRSSLTAVT	DEG_APCC_DBOX_1	0.1389
p.A29T	TCGA-AG-3892	READ	TCGA	PRSSLTAVT	DEG_APCC_DBOX_1	0.2222
p.A29T	DO36394	READ	ICGC	PRSSLTAVT	DEG_APCC_DBOX_1	0.2222
p.A29T	ACH-000999	Colon/Colorectal Cancer	CCLE	PRSSLTAVT	DEG_APCC_DBOX_1	0.2222
p.A29T	SNU-1040	large_intestine	COSMIC	PRSSLTAVT	DEG_APCC_DBOX_1	0.2222
p.S24F	TCGA-CA-6718	COAD	TCGA	PRSSLTAVT	DEG_APCC_DBOX_1	0.5278
p.S24F	DO7801	COAD	ICGC	PRSSLTAVT	DEG_APCC_DBOX_1	0.5278
p.T41N	TCGA-D8-A1J8	BRCA	TCGA	PRSSLTAVT	DEG_APCC_DBOX_1	0.5944
p.T41N	DO1269	BRCA	ICGC	PRSSLTAVT	DEG_APCC_DBOX_1	0.5944
p.Q25P	TCGA-OR-A5KB	ACC	TCGA	PRSSLTAVT	DEG_APCC_DBOX_1	0.1111
p.A39S	DO229041	LICA	ICGC	PRSSLTAVT	DEG_APCC_DBOX_1	0.6477
p.K47Q	SIDM01640	Acute Myeloid Leukemia	GDSC	PRSSLTAVT	DEG_APCC_DBOX_1	0.2778
p.K47Q	ACH-000602	Leukemia	CCLE	PRSSLTAVT	DEG_APCC_DBOX_1	0.2778
p.A29G	ACH-001369	Ovarian Cancer	CCLE	PRSSLTAVT	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NTX9	Protein FAM217B	DEG_APCC_DBOX_1	33:41	PRSSLTAVT	APC,CDC20,FZR1	0.5201	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons