DegronMD

Uniprot ID: P08887

Source protein: Interleukin-6 receptor subunit alpha

Source gene: IL6R

Class: DEG_SCF_FBW7_1

Location: 136:143

E3 ligase: FBXW7

DEGRON score: 0.661

ASA_SCORE: 73.3125

COIL: 0.8303

CONS_SCORE: 0.4236

DSS_SCORE: 0.2578

HELIX: 0.0375

FCONS_SCORE: 0.7438

RIG_SCORE: 0.7246

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R137L	TCGA-05-4396	LUAD	TCGA	PRSTPSLT	DEG_SCF_FBW7_1	0.7316
p.R137L	DO23838	LUAD	ICGC	PRSTPSLT	DEG_SCF_FBW7_1	0.7316
p.V147M	TCGA-A5-A0G2	UCEC	TCGA	PRSTPSLT	DEG_SCF_FBW7_1	0.2222
p.V147M	DO41235	UCEC	ICGC	PRSTPSLT	DEG_SCF_FBW7_1	0.2222
p.P136L	TCGA-DA-A3F3	SKCM	TCGA	PRSTPSLT	DEG_SCF_FBW7_1	0.6471
p.P136L	DO37607	SKCM	ICGC	PRSTPSLT	DEG_SCF_FBW7_1	0.6471
p.P126H	TCGA-EE-A2MC	SKCM	TCGA	PRSTPSLT	DEG_SCF_FBW7_1	0.0556
p.P126H	DO37559	SKCM	ICGC	PRSTPSLT	DEG_SCF_FBW7_1	0.0556
p.S141F	TCGA-FS-A1ZK	SKCM	TCGA	PRSTPSLT	DEG_SCF_FBW7_1	0.7982
p.S141F	DO37474	SKCM	ICGC	PRSTPSLT	DEG_SCF_FBW7_1	0.7982
p.K145N	TCGA-MA-AA42	CESC	TCGA	PRSTPSLT	DEG_SCF_FBW7_1	0.2778
p.K145N	DO219724	CESC	ICGC	PRSTPSLT	DEG_SCF_FBW7_1	0.2778
p.V150L	DO1140	BRCA	ICGC	PRSTPSLT	DEG_SCF_FBW7_1	0.1389
p.T139I	DO222794	COCA	ICGC	PRSTPSLT	DEG_SCF_FBW7_1	0.8189
p.S141Y	DO23260	LINC	ICGC	PRSTPSLT	DEG_SCF_FBW7_1	0.712
p.S141Y	SIDM00321	Ovarian Carcinoma	GDSC	PRSTPSLT	DEG_SCF_FBW7_1	0.712
p.S141Y	ACH-000430	Ovarian Cancer	CCLE	PRSTPSLT	DEG_SCF_FBW7_1	0.712
p.S141Y	TYK-nu	ovary	COSMIC	PRSTPSLT	DEG_SCF_FBW7_1	0.712
p.P136A	DO228872	MALY	ICGC	PRSTPSLT	DEG_SCF_FBW7_1	0.7503
p.R137Q	DO220851	MELA	ICGC	PRSTPSLT	DEG_SCF_FBW7_1	0.6218
p.R137Q	ACH-000831	Endometrial/Uterine Cancer	CCLE	PRSTPSLT	DEG_SCF_FBW7_1	0.6218
p.W134G	DO229229	THCA	ICGC	PRSTPSLT	DEG_SCF_FBW7_1	0.2778
p.F153I	SIDM01953	Colorectal Carcinoma	GDSC	PRSTPSLT	DEG_SCF_FBW7_1	0.0556
p.P140Q	SIDM00999	Bladder Carcinoma	GDSC	PRSTPSLT	DEG_SCF_FBW7_1	0.7035
p.P140Q	ACH-000973	Bladder Cancer	CCLE	PRSTPSLT	DEG_SCF_FBW7_1	0.7035
p.P140Q	639-V	urinary_tract	COSMIC	PRSTPSLT	DEG_SCF_FBW7_1	0.7035

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08887	Interleukin-6 receptor subunit alpha	DEG_SCF_FBW7_1	136:143	PRSTPSLT	FBXW7	0.661	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRSTPSLT

Degron related mutations and impact score

Drug responses associated with IL6R mutations

All proteins holding degron of PRSTPSLT