DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PRTLLLLLS
Uniprot ID:
P01893
Source protein:
Putative HLA class I histocompatibility antigen, alpha chain H
Source gene:
HLA-H
Class:
DEG_APCC_DBOX_1
Location:
6:14
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5475
ASA_SCORE:
65.1222
COIL:
0.1662
CONS_SCORE:
0.4846
DSS_SCORE:
0.0416
HELIX:
0.8136
FCONS_SCORE:
1.2738
RIG_SCORE:
0.9278
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with HLA-H mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PRTLLLLLS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P01893
Putative HLA class I histocompatibility antigen, alpha chain H
DEG_APCC_DBOX_1
6:14
PRTLLLLLS
APC,CDC20,FZR1
0.5475
More...