DegronMD

Uniprot ID: P47928

Source protein: DNA-binding protein inhibitor ID-4

Source gene: ID4

Class: DEG_APCC_DBOX_1

Location: 136:144

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9957

ASA_SCORE: 72.0444

COIL: 0.7061

CONS_SCORE: 0.536

DSS_SCORE: 0.6435

HELIX: 0.21

FCONS_SCORE: 1.4246

RIG_SCORE: 0.6757

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P127A	DO228589	LICA	ICGC	PRTPLTALN	DEG_APCC_DBOX_1	0.0833
p.P136L	DO23308	LINC	ICGC	PRTPLTALN	DEG_APCC_DBOX_1	0.6471
p.T141N	DO229229	THCA	ICGC	PRTPLTALN	DEG_APCC_DBOX_1	0.5944
p.C131Y	SIDM01040	Ovarian Carcinoma	GDSC	PRTPLTALN	DEG_APCC_DBOX_1	0.1944
p.C131Y	ACH-000574	Ovarian Cancer	CCLE	PRTPLTALN	DEG_APCC_DBOX_1	0.1944
p.G149D	SIDM01175	Other Sarcomas	GDSC	PRTPLTALN	DEG_APCC_DBOX_1	0.1944
p.G149D	ACH-002309	Sarcoma	CCLE	PRTPLTALN	DEG_APCC_DBOX_1	0.1944
p.G149D	SW684	soft_tissue	COSMIC	PRTPLTALN	DEG_APCC_DBOX_1	0.1944
p.A128V	ACH-000790	Lung Cancer	CCLE	PRTPLTALN	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P47928	DNA-binding protein inhibitor ID-4	DEG_APCC_DBOX_1	136:144	PRTPLTALN	APC,CDC20,FZR1	0.9957	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons