DegronMD

Uniprot ID: Q9Y3Z3

Source protein: Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

Source gene: SAMHD1

Class: DEG_SCF_FBW7_1

Location: 19:25

E3 ligase: FBXW7

DEGRON score: 0.9129

ASA_SCORE: 90.6571

COIL: 0.9579

CONS_SCORE: 0.2462

DSS_SCORE: 0.7374

HELIX: 0.0206

FCONS_SCORE: 1.0339

RIG_SCORE: 0.5217

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R20K	TCGA-A5-A2K5	UCEC	TCGA	PRTPSNT	DEG_SCF_FBW7_1	0.6126
p.R20K	DO41379	UCEC	ICGC	PRTPSNT	DEG_SCF_FBW7_1	0.6126
p.R20I	TCGA-AX-A2HC	UCEC	TCGA	PRTPSNT	DEG_SCF_FBW7_1	0.6991
p.R20I	TCGA-EY-A1G8	UCEC	TCGA	PRTPSNT	DEG_SCF_FBW7_1	0.6991
p.R20I	DO43578	UCEC	ICGC	PRTPSNT	DEG_SCF_FBW7_1	0.6991
p.R20I	DO41572	UCEC	ICGC	PRTPSNT	DEG_SCF_FBW7_1	0.6991
p.D17N	TCGA-VQ-A8P2	STAD	TCGA	PRTPSNT	DEG_SCF_FBW7_1	0.2778
p.D17N	DO51761	STAD	ICGC	PRTPSNT	DEG_SCF_FBW7_1	0.2778
p.S18R	DO228971	LICA	ICGC	PRTPSNT	DEG_SCF_FBW7_1	0.75
p.S18R	DO229211	THCA	ICGC	PRTPSNT	DEG_SCF_FBW7_1	0.75
p.D31E	DO229026	LICA	ICGC	PRTPSNT	DEG_SCF_FBW7_1	0.1667
p.S33F	ACH-001379	Pancreatic Cancer	CCLE	PRTPSNT	DEG_SCF_FBW7_1	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y3Z3	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	DEG_SCF_FBW7_1	19:25	PRTPSNT	FBXW7	0.9129	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons