DegronMD

Uniprot ID: P0DI83

Source protein: Ras-related protein Rab-34, isoform NARR

Source gene: RAB34

Class: DEG_SCF_FBW7_1

Location: 99:105

E3 ligase: FBXW7

DEGRON score: 0.9984

ASA_SCORE: 78.1143

COIL: 0.8654

CONS_SCORE: 0

DSS_SCORE: 0.3674

HELIX: 0.0161

FCONS_SCORE: 0

RIG_SCORE: 0.6475

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K111N	TCGA-CD-A4MG	STAD	TCGA	PRTPVGS	DEG_SCF_FBW7_1	0.1667
p.K111N	TCGA-D5-6928	COAD	TCGA	PRTPVGS	DEG_SCF_FBW7_1	0.1667
p.R93Q	DO8778	COAD	ICGC	PRTPVGS	DEG_SCF_FBW7_1	0.1667
p.W106L	DO8447	COAD	ICGC	PRTPVGS	DEG_SCF_FBW7_1	0.3056
p.G110V	DO222503	COCA	ICGC	PRTPVGS	DEG_SCF_FBW7_1	0.1944
p.P100T	DO228952	LICA	ICGC	PRTPVGS	DEG_SCF_FBW7_1	0.7031
p.L97M	DO229037	LICA	ICGC	PRTPVGS	DEG_SCF_FBW7_1	0.2778
p.G98C	DO230937	LUSC	ICGC	PRTPVGS	DEG_SCF_FBW7_1	0.3056
p.G98C	DO224619	LUSC	ICGC	PRTPVGS	DEG_SCF_FBW7_1	0.3056
p.E95Q	DO27081	LUSC	ICGC	PRTPVGS	DEG_SCF_FBW7_1	0.2222
p.A109T	DO38723	STAD	ICGC	PRTPVGS	DEG_SCF_FBW7_1	0.2222
p.S111T	SIDM00217	Colorectal Carcinoma	GDSC	PRTPVGS	DEG_SCF_FBW7_1	0.1667
p.S111T	SNU-1040	large_intestine	COSMIC	PRTPVGS	DEG_SCF_FBW7_1	0.1667
p.R92H	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PRTPVGS	DEG_SCF_FBW7_1	0.1389
p.R92H	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PRTPVGS	DEG_SCF_FBW7_1	0.1389
p.A96T	SIDM01770	Gastric Carcinoma	GDSC	PRTPVGS	DEG_SCF_FBW7_1	0.6944
p.G110R	ACH-001061	Colon/Colorectal Cancer	CCLE	PRTPVGS	DEG_SCF_FBW7_1	0.1944
p.L103V	ACH-001136	Lung Cancer	CCLE	PRTPVGS	DEG_SCF_FBW7_1	0.6765
p.L103V	NCI-H187	lung	COSMIC	PRTPVGS	DEG_SCF_FBW7_1	0.6765
p.G110W	ACH-002017	Eye Cancer	CCLE	PRTPVGS	DEG_SCF_FBW7_1	0.1944
p.L104V	NCI-H187	lung	COSMIC	PRTPVGS	DEG_SCF_FBW7_1	0.6765
p.G102E	AU565	breast	COSMIC	PRTPVGS	DEG_SCF_FBW7_1	0.7199
p.A105S	LoVo	large_intestine	COSMIC	PRTPVGS	DEG_SCF_FBW7_1	0.7588

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P0DI83	Ras-related protein Rab-34, isoform NARR	DEG_SCF_FBW7_1	99:105	PRTPVGS	FBXW7	0.9984	More...
Q9Y2I7	1-phosphatidylinositol 3-phosphate 5-kinase	DEG_SCF_FBW7_1	251:257	PRTPVGS	FBXW7	0.7907	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons