DegronMD

Uniprot ID: Q9NS56

Source protein: E3 ubiquitin-protein ligase Topors

Source gene: TOPORS

Class: DEG_APCC_DBOX_1

Location: 1029:1037

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6159

ASA_SCORE: 72.8333

COIL: 0.5084

CONS_SCORE: 0.3285

DSS_SCORE: 0.49

HELIX: 0.3408

FCONS_SCORE: 1.022

RIG_SCORE: 0.7285

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1030L	TCGA-44-7659	LUAD	TCGA	PRTSLMSVC	DEG_APCC_DBOX_1	0.8428
p.D1041G	TCGA-97-7938	LUAD	TCGA	PRTSLMSVC	DEG_APCC_DBOX_1	0.2222
p.L1038V	TCGA-CG-4438	STAD	TCGA	PRTSLMSVC	DEG_APCC_DBOX_1	0.3056
p.R1030W	TCGA-EL-A3ZH	THCA	TCGA	PRTSLMSVC	DEG_APCC_DBOX_1	0.8634
p.S1032L	TCGA-GN-A266	SKCM	TCGA	PRTSLMSVC	DEG_APCC_DBOX_1	0.6556
p.D1041Y	SIDM00216	Colorectal Carcinoma	GDSC	PRTSLMSVC	DEG_APCC_DBOX_1	0.2222
p.D1041Y	ACH-000989	Colon/Colorectal Cancer	CCLE	PRTSLMSVC	DEG_APCC_DBOX_1	0.2222
p.D1041Y	SNU-175	large_intestine	COSMIC	PRTSLMSVC	DEG_APCC_DBOX_1	0.2222
p.S1028L	SIDM00995	Other Solid Cancers	GDSC	PRTSLMSVC	DEG_APCC_DBOX_1	0.75
p.S1028L	ACH-001328	Skin Cancer	CCLE	PRTSLMSVC	DEG_APCC_DBOX_1	0.75
p.S1028L	A431	skin	COSMIC	PRTSLMSVC	DEG_APCC_DBOX_1	0.75
p.D1043V	SIDM00333	Endometrial Carcinoma	GDSC	PRTSLMSVC	DEG_APCC_DBOX_1	0.1667
p.D1043V	ACH-000988	Endometrial/Uterine Cancer	CCLE	PRTSLMSVC	DEG_APCC_DBOX_1	0.1667
p.D1043V	MFE-319	endometrium	COSMIC	PRTSLMSVC	DEG_APCC_DBOX_1	0.1667
p.C1042Y	SIDM01609	Endometrial Carcinoma	GDSC	PRTSLMSVC	DEG_APCC_DBOX_1	0.1944
p.C1042Y	ACH-000972	Endometrial/Uterine Cancer	CCLE	PRTSLMSVC	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NS56	E3 ubiquitin-protein ligase Topors	DEG_APCC_DBOX_1	1029:1037	PRTSLMSVC	APC,CDC20,FZR1	0.6159	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons