DegronMD

Uniprot ID: Q13263

Source protein: Transcription intermediary factor 1-beta

Source gene: TRIM28

Class: DEG_APCC_DBOX_1

Location: 486:494

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8498

ASA_SCORE: 87.4444

COIL: 0.6548

CONS_SCORE: 0.2825

DSS_SCORE: 0.3559

HELIX: 0.2198

FCONS_SCORE: 0.6706

RIG_SCORE: 0.8081

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D496N	TCGA-2W-A8YY	CESC	TCGA	PRVSLERLD	DEG_APCC_DBOX_1	0.2778
p.D496N	DO223732	CESC	ICGC	PRVSLERLD	DEG_APCC_DBOX_1	0.2778
p.G480S	TCGA-B5-A3FC	UCEC	TCGA	PRVSLERLD	DEG_APCC_DBOX_1	0.1667
p.G480S	DO41871	UCEC	ICGC	PRVSLERLD	DEG_APCC_DBOX_1	0.1667
p.R483H	TCGA-B5-A3FC	UCEC	TCGA	PRVSLERLD	DEG_APCC_DBOX_1	0.25
p.R483H	DO232761	PBCA	ICGC	PRVSLERLD	DEG_APCC_DBOX_1	0.25
p.R483H	DO41871	UCEC	ICGC	PRVSLERLD	DEG_APCC_DBOX_1	0.25
p.R492C	TCGA-D3-A1Q1	SKCM	TCGA	PRVSLERLD	DEG_APCC_DBOX_1	0.719
p.R492C	DO37445	SKCM	ICGC	PRVSLERLD	DEG_APCC_DBOX_1	0.719
p.R492C	SIDM00403	T-Lymphoblastic Leukemia	GDSC	PRVSLERLD	DEG_APCC_DBOX_1	0.719
p.R492C	ACH-000636	Leukemia	CCLE	PRVSLERLD	DEG_APCC_DBOX_1	0.719
p.R492C	RPMI-8402	haematopoietic_and_lymphoid_tissue	COSMIC	PRVSLERLD	DEG_APCC_DBOX_1	0.719
p.E491D	TCGA-KK-A8IC	PRAD	TCGA	PRVSLERLD	DEG_APCC_DBOX_1	0.5647
p.E501K	DO457	BLCA	ICGC	PRVSLERLD	DEG_APCC_DBOX_1	0.5833
p.G476S	DO233140	GACA	ICGC	PRVSLERLD	DEG_APCC_DBOX_1	0.0556
p.P503A	DO27349	LUSC	ICGC	PRVSLERLD	DEG_APCC_DBOX_1	0.0833
p.E501D	DO42673	UCEC	ICGC	PRVSLERLD	DEG_APCC_DBOX_1	0.5833
p.Q502H	SIDM01051	Ovarian Carcinoma	GDSC	PRVSLERLD	DEG_APCC_DBOX_1	0.1111
p.Q502H	ACH-000936	Ovarian Cancer	CCLE	PRVSLERLD	DEG_APCC_DBOX_1	0.1111
p.Q502H	EFO-27	ovary	COSMIC	PRVSLERLD	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13263	Transcription intermediary factor 1-beta	DEG_APCC_DBOX_1	486:494	PRVSLERLD	APC,CDC20,FZR1	0.8498	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons