DegronMD

Uniprot ID: P82932

Source protein: 28S ribosomal protein S6, mitochondrial

Source gene: MRPS6

Class: DEG_APCC_DBOX_1

Location: 2:10

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7923

ASA_SCORE: 24.7889

COIL: 0.2157

CONS_SCORE: 0.5722

DSS_SCORE: 0.4678

HELIX: 0.0044

FCONS_SCORE: 1.2654

RIG_SCORE: 0.8778

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R15L	TCGA-D3-A2JP	SKCM	TCGA	PRYELALIL	DEG_APCC_DBOX_1	0.1944
p.R15L	DO47407	SKCM	ICGC	PRYELALIL	DEG_APCC_DBOX_1	0.1944
p.A19S	DO231788	LINC	ICGC	PRYELALIL	DEG_APCC_DBOX_1	0.0833
p.T18I	SIDM00516	Melanoma	GDSC	PRYELALIL	DEG_APCC_DBOX_1	0.5556
p.T18I	ACH-002166	Skin Cancer	CCLE	PRYELALIL	DEG_APCC_DBOX_1	0.5556
p.T18I	MZ7-mel	skin	COSMIC	PRYELALIL	DEG_APCC_DBOX_1	0.5556
p.L8S	ACH-000909	Endometrial/Uterine Cancer	CCLE	PRYELALIL	DEG_APCC_DBOX_1	0.6556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P82932	28S ribosomal protein S6, mitochondrial	DEG_APCC_DBOX_1	2:10	PRYELALIL	APC,CDC20,FZR1	0.7923	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons