DegronMD

Uniprot ID: Q9NW08

Source protein: DNA-directed RNA polymerase III subunit RPC2

Source gene: POLR3B

Class: DEG_SCF_FBW7_2

Location: 481:488

E3 ligase: FBXW7

DEGRON score: 0.5791

ASA_SCORE: 60.825

COIL: 0.8403

CONS_SCORE: 0.8014

DSS_SCORE: 0.3694

HELIX: 0.0835

FCONS_SCORE: 1.1654

RIG_SCORE: 0.7002

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D483N	TCGA-06-0213	GBM	TCGA	PSDTPEGE	DEG_SCF_FBW7_2	0.5821
p.P481S	TCGA-EE-A2MJ	SKCM	TCGA	PSDTPEGE	DEG_SCF_FBW7_2	0.6752
p.P481L	TCGA-EE-A2MJ	SKCM	TCGA	PSDTPEGE	DEG_SCF_FBW7_2	0.6471
p.P481L	TCGA-GN-A8LK	SKCM	TCGA	PSDTPEGE	DEG_SCF_FBW7_2	0.6471
p.P481L	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	PSDTPEGE	DEG_SCF_FBW7_2	0.6471
p.P481R	TCGA-EE-A3AG	SKCM	TCGA	PSDTPEGE	DEG_SCF_FBW7_2	0.7512
p.N477S	DO26822	LUSC	ICGC	PSDTPEGE	DEG_SCF_FBW7_2	0.2222
p.R492Q	DO232224	PBCA	ICGC	PSDTPEGE	DEG_SCF_FBW7_2	0.2222
p.V498L	DO219491	SKCM	ICGC	PSDTPEGE	DEG_SCF_FBW7_2	0.0556
p.N477H	DO43186	UCEC	ICGC	PSDTPEGE	DEG_SCF_FBW7_2	0.2222
p.N486T	DO43971	UCEC	ICGC	PSDTPEGE	DEG_SCF_FBW7_2	0.7055
p.A489T	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	PSDTPEGE	DEG_SCF_FBW7_2	0.3056
p.A489T	KYSE-140	oesophagus	COSMIC	PSDTPEGE	DEG_SCF_FBW7_2	0.3056
p.S482L	ACH-002089	Lung Cancer	CCLE	PSDTPEGE	DEG_SCF_FBW7_2	0.6556
p.S482L	201T	lung	COSMIC	PSDTPEGE	DEG_SCF_FBW7_2	0.6556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NW08	DNA-directed RNA polymerase III subunit RPC2	DEG_SCF_FBW7_2	481:488	PSDTPEGE	FBXW7	0.5791	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons