DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
PSKTPHPE
Uniprot ID:
I3L273
Source protein:
Golgi-associated olfactory signaling regulator
Source gene:
GFY
Class:
DEG_SCF_FBW7_2
Location:
237:244
E3 ligase:
FBXW7
DEGRON score:
0.922
ASA_SCORE:
98.6625
COIL:
0.9604
CONS_SCORE:
0
DSS_SCORE:
0.8201
HELIX:
0.0158
FCONS_SCORE:
0
RIG_SCORE:
0.4907
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with GFY mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PSKTPHPE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
I3L273
Golgi-associated olfactory signaling regulator
DEG_SCF_FBW7_2
237:244
PSKTPHPE
FBXW7
0.922
More...