DegronMD

Uniprot ID: Q9Y3Z3

Source protein: Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

Source gene: SAMHD1

Class: DEG_SCF_FBW7_2

Location: 22:29

E3 ligase: FBXW7

DEGRON score: 0.9974

ASA_SCORE: 80.6625

COIL: 0.8761

CONS_SCORE: 0.2644

DSS_SCORE: 0.7028

HELIX: 0.1001

FCONS_SCORE: 1.1181

RIG_SCORE: 0.5621

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D17N	TCGA-VQ-A8P2	STAD	TCGA	PSNTPSAE	DEG_SCF_FBW7_2	0.1944
p.D17N	DO51761	STAD	ICGC	PSNTPSAE	DEG_SCF_FBW7_2	0.1944
p.S27F	TCGA-ZF-A9R2	BLCA	TCGA	PSNTPSAE	DEG_SCF_FBW7_2	0.7982
p.S27F	DO219058	BLCA	ICGC	PSNTPSAE	DEG_SCF_FBW7_2	0.7982
p.S18R	DO228971	LICA	ICGC	PSNTPSAE	DEG_SCF_FBW7_2	0.6667
p.S18R	DO229211	THCA	ICGC	PSNTPSAE	DEG_SCF_FBW7_2	0.6667
p.D31E	DO229026	LICA	ICGC	PSNTPSAE	DEG_SCF_FBW7_2	0.2778
p.P26L	SIDM00087	Plasma Cell Myeloma	GDSC	PSNTPSAE	DEG_SCF_FBW7_2	0.7582
p.P26L	SIDM00846	Cervical Carcinoma	GDSC	PSNTPSAE	DEG_SCF_FBW7_2	0.7582
p.P26L	SIDM00493	Other Solid Cancers	GDSC	PSNTPSAE	DEG_SCF_FBW7_2	0.7582
p.S33F	ACH-001379	Pancreatic Cancer	CCLE	PSNTPSAE	DEG_SCF_FBW7_2	0.6667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y3Z3	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	DEG_SCF_FBW7_2	22:29	PSNTPSAE	FBXW7	0.9974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons