DegronMD

Uniprot ID: Q9NZJ0

Source protein: Denticleless protein homolog

Source gene: DTL

Class: DEG_SCF_FBW7_1

Location: 461:468

E3 ligase: FBXW7

DEGRON score: 0.9841

ASA_SCORE: 55.8875

COIL: 0.6608

CONS_SCORE: 0.4462

DSS_SCORE: 0.515

HELIX: 0.1886

FCONS_SCORE: 1.0664

RIG_SCORE: 0.6732

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L460V	TCGA-62-A471	LUAD	TCGA	PSNTPTFS	DEG_SCF_FBW7_1	0.3056
p.P465L	TCGA-YG-AA3N	SKCM	TCGA	PSNTPTFS	DEG_SCF_FBW7_1	0.7582
p.F455L	DO44029	BLCA	ICGC	PSNTPTFS	DEG_SCF_FBW7_1	0.1667
p.S478L	DO223592	BLCA	ICGC	PSNTPTFS	DEG_SCF_FBW7_1	0.5
p.S478L	DO41927	UCEC	ICGC	PSNTPTFS	DEG_SCF_FBW7_1	0.5
p.T474P	DO228297	LICA	ICGC	PSNTPTFS	DEG_SCF_FBW7_1	0.1667
p.P475L	DO47706	SKCM	ICGC	PSNTPTFS	DEG_SCF_FBW7_1	0.25
p.P451L	DO37936	SKCM	ICGC	PSNTPTFS	DEG_SCF_FBW7_1	0.0556
p.R465Q	DO41020	UCEC	ICGC	PSNTPTFS	DEG_SCF_FBW7_1	0.7329
p.R477Q	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	PSNTPTFS	DEG_SCF_FBW7_1	0.0833
p.R477Q	ACH-000561	Esophageal Cancer	CCLE	PSNTPTFS	DEG_SCF_FBW7_1	0.0833
p.R477Q	T-T	oesophagus	COSMIC	PSNTPTFS	DEG_SCF_FBW7_1	0.0833
p.A474S	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	PSNTPTFS	DEG_SCF_FBW7_1	0.1667
p.A474S	ACH-000509	Lymphoma	CCLE	PSNTPTFS	DEG_SCF_FBW7_1	0.1667
p.A474S	ACH-002240	Lymphoma	CCLE	PSNTPTFS	DEG_SCF_FBW7_1	0.1667
p.A474S	H9	haematopoietic_and_lymphoid_tissue	COSMIC	PSNTPTFS	DEG_SCF_FBW7_1	0.1667
p.L460F	SIDM01128	Small Cell Lung Carcinoma	GDSC	PSNTPTFS	DEG_SCF_FBW7_1	0.3056
p.L460F	ACH-000767	Lung Cancer	CCLE	PSNTPTFS	DEG_SCF_FBW7_1	0.3056
p.L460F	NCI-H526	lung	COSMIC	PSNTPTFS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZJ0	Denticleless protein homolog	DEG_SCF_FBW7_1	461:468	PSNTPTFS	FBXW7	0.9841	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons