DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
PSRTPQCE
Uniprot ID:
Q00653
Source protein:
Nuclear factor NF-kappa-B p100 subunit
Source gene:
NFKB2
Class:
DEG_SCF_FBW7_2
Location:
426:433
E3 ligase:
FBXW7
DEGRON score:
0.7638
ASA_SCORE:
68.75
COIL:
0.823
CONS_SCORE:
0.3472
DSS_SCORE:
0.7614
HELIX:
0.1041
FCONS_SCORE:
0.9547
RIG_SCORE:
0.6018
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R428S
DO229012
LICA
ICGC
PSRTPQCE
DEG_SCF_FBW7_2
0.6316
p.P430S
SIDM00224
Mesothelioma
GDSC
PSRTPQCE
DEG_SCF_FBW7_2
0.6752
Drug responses associated with NFKB2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PSRTPQCE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q00653
Nuclear factor NF-kappa-B p100 subunit
DEG_SCF_FBW7_2
426:433
PSRTPQCE
FBXW7
0.7638
More...