DegronMD

Uniprot ID: Q86Y91

Source protein: Kinesin-like protein KIF18B

Source gene: KIF18B

Class: DEG_SCF_FBW7_2

Location: 672:678

E3 ligase: FBXW7

DEGRON score: 0.7313

ASA_SCORE: 93.1857

COIL: 0.9423

CONS_SCORE: 0.4476

DSS_SCORE: 0.7926

HELIX: 0.0277

FCONS_SCORE: 0.956

RIG_SCORE: 0.5186

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G677A	TCGA-DA-A3F5	SKCM	TCGA	PSTPKGE	DEG_SCF_FBW7_2	0.6429
p.G671W	TCGA-G7-6797	KIRP	TCGA	PSTPKGE	DEG_SCF_FBW7_2	0.3056
p.T666I	TCGA-YD-A9TA	SKCM	TCGA	PSTPKGE	DEG_SCF_FBW7_2	0.6111
p.C669Y	DO230311	COCA	ICGC	PSTPKGE	DEG_SCF_FBW7_2	0.6944
p.G683W	DO20917	KIRP	ICGC	PSTPKGE	DEG_SCF_FBW7_2	0.1944
p.P680T	DO229045	LICA	ICGC	PSTPKGE	DEG_SCF_FBW7_2	0.2778
p.T678I	DO219503	SKCM	ICGC	PSTPKGE	DEG_SCF_FBW7_2	0.7078
p.G673W	DO42280	UCEC	ICGC	PSTPKGE	DEG_SCF_FBW7_2	0.7825
p.P668S	DO41871	UCEC	ICGC	PSTPKGE	DEG_SCF_FBW7_2	0.2222
p.P672L	SIDM00371	Pancreatic Carcinoma	GDSC	PSTPKGE	DEG_SCF_FBW7_2	0.6471
p.P672L	SIDM00590	Oral Cavity Carcinoma	GDSC	PSTPKGE	DEG_SCF_FBW7_2	0.6471
p.P672L	SIDM00489	Oral Cavity Carcinoma	GDSC	PSTPKGE	DEG_SCF_FBW7_2	0.6471
p.P672L	SIDM00214	Colorectal Carcinoma	GDSC	PSTPKGE	DEG_SCF_FBW7_2	0.6471
p.P672L	SIDM00247	Gastric Carcinoma	GDSC	PSTPKGE	DEG_SCF_FBW7_2	0.6471
p.P672L	SIDM00045	Gastric Carcinoma	GDSC	PSTPKGE	DEG_SCF_FBW7_2	0.6471
p.P672L	SIDM01608	Endometrial Carcinoma	GDSC	PSTPKGE	DEG_SCF_FBW7_2	0.6471
p.P672L	SIDM00008	Ovarian Carcinoma	GDSC	PSTPKGE	DEG_SCF_FBW7_2	0.6471
p.P672L	SIDM01575	Plasma Cell Myeloma	GDSC	PSTPKGE	DEG_SCF_FBW7_2	0.6471
p.P672L	HSC-39	stomach	COSMIC	PSTPKGE	DEG_SCF_FBW7_2	0.6471
p.P672L	SNU-407	large_intestine	COSMIC	PSTPKGE	DEG_SCF_FBW7_2	0.6471
p.P672L	MKN45	stomach	COSMIC	PSTPKGE	DEG_SCF_FBW7_2	0.6471
p.P672L	Ca9-22	upper_aerodigestive_tract	COSMIC	PSTPKGE	DEG_SCF_FBW7_2	0.6471
p.P672L	SUIT-2	pancreas	COSMIC	PSTPKGE	DEG_SCF_FBW7_2	0.6471
p.P672L	HSC-2	upper_aerodigestive_tract	COSMIC	PSTPKGE	DEG_SCF_FBW7_2	0.6471
p.R688H	SIDM00999	Bladder Carcinoma	GDSC	PSTPKGE	DEG_SCF_FBW7_2	0.0556
p.R688H	SIDM00118	Colorectal Carcinoma	GDSC	PSTPKGE	DEG_SCF_FBW7_2	0.0556
p.R688H	ACH-000973	Bladder Cancer	CCLE	PSTPKGE	DEG_SCF_FBW7_2	0.0556
p.R688H	ACH-001081	Colon/Colorectal Cancer	CCLE	PSTPKGE	DEG_SCF_FBW7_2	0.0556
p.R688H	639-V	urinary_tract	COSMIC	PSTPKGE	DEG_SCF_FBW7_2	0.0556
p.R688H	HCC2998	large_intestine	COSMIC	PSTPKGE	DEG_SCF_FBW7_2	0.0556
p.G671V	ACH-001518	Endometrial/Uterine Cancer	CCLE	PSTPKGE	DEG_SCF_FBW7_2	0.3056
p.G677R	ACH-002458	Skin Cancer	CCLE	PSTPKGE	DEG_SCF_FBW7_2	0.6457
p.P684L	SNU-407	large_intestine	COSMIC	PSTPKGE	DEG_SCF_FBW7_2	0.1667
p.P684L	HSC-2	upper_aerodigestive_tract	COSMIC	PSTPKGE	DEG_SCF_FBW7_2	0.1667
p.P684L	SUIT-2	pancreas	COSMIC	PSTPKGE	DEG_SCF_FBW7_2	0.1667
p.P684L	Ca9-22	upper_aerodigestive_tract	COSMIC	PSTPKGE	DEG_SCF_FBW7_2	0.1667
p.P684L	HSC-39	stomach	COSMIC	PSTPKGE	DEG_SCF_FBW7_2	0.1667
p.P684L	MKN45	stomach	COSMIC	PSTPKGE	DEG_SCF_FBW7_2	0.1667
p.R672H	PL4	pancreas	COSMIC	PSTPKGE	DEG_SCF_FBW7_2	0.8244
p.R663H	PL4	pancreas	COSMIC	PSTPKGE	DEG_SCF_FBW7_2	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSTPKGE

Degron related mutations and impact score

Drug responses associated with KIF18B mutations

All proteins holding degron of PSTPKGE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86Y91	Kinesin-like protein KIF18B	DEG_SCF_FBW7_2	672:678	PSTPKGE	FBXW7	0.7313	More...