DegronMD

Uniprot ID: Q6P5Q4

Source protein: Leiomodin-2

Source gene: LMOD2

Class: DEG_SCF_FBW7_1

Location: 514:520

E3 ligase: FBXW7

DEGRON score: 0.5741

ASA_SCORE: 86.7714

COIL: 0.9003

CONS_SCORE: 0.5917

DSS_SCORE: 0.7357

HELIX: 0.0299

FCONS_SCORE: 1.0403

RIG_SCORE: 0.5748

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P514H	TCGA-A5-A1OF	UCEC	TCGA	PSTPQRS	DEG_SCF_FBW7_1	0.7694
p.P514H	DO42568	UCEC	ICGC	PSTPQRS	DEG_SCF_FBW7_1	0.7694
p.A528T	TCGA-AC-A23H	BRCA	TCGA	PSTPQRS	DEG_SCF_FBW7_1	0.1111
p.A528T	DO2401	BRCA	ICGC	PSTPQRS	DEG_SCF_FBW7_1	0.1111
p.Q518H	TCGA-AX-A1CE	UCEC	TCGA	PSTPQRS	DEG_SCF_FBW7_1	0.647
p.Q518H	DO42280	UCEC	ICGC	PSTPQRS	DEG_SCF_FBW7_1	0.647
p.R530W	TCGA-BK-A6W3	UCEC	TCGA	PSTPQRS	DEG_SCF_FBW7_1	0.0556
p.R530W	TCGA-CA-6718	COAD	TCGA	PSTPQRS	DEG_SCF_FBW7_1	0.0556
p.R530W	TCGA-D1-A17Q	UCEC	TCGA	PSTPQRS	DEG_SCF_FBW7_1	0.0556
p.R530W	DO7801	COAD	ICGC	PSTPQRS	DEG_SCF_FBW7_1	0.0556
p.R530W	DO50076	UCEC	ICGC	PSTPQRS	DEG_SCF_FBW7_1	0.0556
p.R530W	DO41903	UCEC	ICGC	PSTPQRS	DEG_SCF_FBW7_1	0.0556
p.R530Q	TCGA-G3-A7M7	LIHC	TCGA	PSTPQRS	DEG_SCF_FBW7_1	0.0556
p.R530Q	DO49693	LIHC	ICGC	PSTPQRS	DEG_SCF_FBW7_1	0.0556
p.A521S	DO233646	GACA	ICGC	PSTPQRS	DEG_SCF_FBW7_1	0.3056
p.K506N	DO233707	GACA	ICGC	PSTPQRS	DEG_SCF_FBW7_1	0.2222
p.P517S	DO229054	LICA	ICGC	PSTPQRS	DEG_SCF_FBW7_1	0.6752
p.R519K	DO220884	MELA	ICGC	PSTPQRS	DEG_SCF_FBW7_1	0.6126
p.I529V	SIDM00683	Prostate Carcinoma	GDSC	PSTPQRS	DEG_SCF_FBW7_1	0.0833
p.I529V	ACH-000179	Lung Cancer	CCLE	PSTPQRS	DEG_SCF_FBW7_1	0.0833
p.I529V	ACH-000977	lymph_node	CCLE	PSTPQRS	DEG_SCF_FBW7_1	0.0833
p.I529V	LNCaP-Clone-FGC	prostate	COSMIC	PSTPQRS	DEG_SCF_FBW7_1	0.0833
p.D510V	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PSTPQRS	DEG_SCF_FBW7_1	0.2222
p.D510V	ACH-000929	Lung Cancer	CCLE	PSTPQRS	DEG_SCF_FBW7_1	0.2222
p.D510V	NCI-H2110	lung	COSMIC	PSTPQRS	DEG_SCF_FBW7_1	0.2222
p.K506M	ACH-000842	Colon/Colorectal Cancer	CCLE	PSTPQRS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P5Q4	Leiomodin-2	DEG_SCF_FBW7_1	514:520	PSTPQRS	FBXW7	0.5741	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSTPQRS

Degron related mutations and impact score

Drug responses associated with LMOD2 mutations

All proteins holding degron of PSTPQRS