DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
PTLTPSQE
Uniprot ID:
P0C860
Source protein:
Putative male-specific lethal-3 protein-like 2
Source gene:
MSL3P1
Class:
DEG_SCF_FBW7_2
Location:
326:333
E3 ligase:
FBXW7
DEGRON score:
0.6742
ASA_SCORE:
88.275
COIL:
0.852
CONS_SCORE:
0.2762
DSS_SCORE:
0.6321
HELIX:
0.1123
FCONS_SCORE:
0.9477
RIG_SCORE:
0.605
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MSL3P1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PTLTPSQE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P0C860
Putative male-specific lethal-3 protein-like 2
DEG_SCF_FBW7_2
326:333
PTLTPSQE
FBXW7
0.6742
More...