DegronMD

Uniprot ID: Q6ZNI0

Source protein: Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7

Source gene: GCNT7

Class: DEG_SCF_FBW7_1

Location: 28:33

E3 ligase: FBXW7

DEGRON score: 0.5721

ASA_SCORE: 85.75

COIL: 0.826

CONS_SCORE: 0.4865

DSS_SCORE: 0.303

HELIX: 0.1617

FCONS_SCORE: 0.9784

RIG_SCORE: 0.7272

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F43L	TCGA-AA-A00N	COAD	TCGA	PTPAES	DEG_SCF_FBW7_1	0.0556
p.F43L	DO9876	COAD	ICGC	PTPAES	DEG_SCF_FBW7_1	0.0556
p.I18S	TCGA-B5-A11E	UCEC	TCGA	PTPAES	DEG_SCF_FBW7_1	0.0556
p.I18S	DO41644	UCEC	ICGC	PTPAES	DEG_SCF_FBW7_1	0.0556
p.L35S	TCGA-EO-A22R	UCEC	TCGA	PTPAES	DEG_SCF_FBW7_1	0.2778
p.L35S	DO42713	UCEC	ICGC	PTPAES	DEG_SCF_FBW7_1	0.2778
p.H19N	TCGA-JW-A5VL	CESC	TCGA	PTPAES	DEG_SCF_FBW7_1	0.0833
p.H19N	DO49976	CESC	ICGC	PTPAES	DEG_SCF_FBW7_1	0.0833
p.L25S	MFE-319	endometrium	COSMIC	PTPAES	DEG_SCF_FBW7_1	0.25
p.V32M	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PTPAES	DEG_SCF_FBW7_1	0.7208

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZNI0	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7	DEG_SCF_FBW7_1	28:33	PTPAES	FBXW7	0.5721	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons