DegronMD

Uniprot ID: Q96MU7

Source protein: YTH domain-containing protein 1

Source gene: YTHDC1

Class: DEG_SCF_FBW7_1

Location: 147:152

E3 ligase: FBXW7

DEGRON score: 0.8684

ASA_SCORE: 85.7667

COIL: 0.9455

CONS_SCORE: 0.357

DSS_SCORE: 0.7184

HELIX: 0.0405

FCONS_SCORE: 0.9541

RIG_SCORE: 0.5659

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R162H	TCGA-AN-A0AK	BRCA	TCGA	PTPDGS	DEG_SCF_FBW7_1	0.0556
p.R162H	DO1608	BRCA	ICGC	PTPDGS	DEG_SCF_FBW7_1	0.0556
p.R154I	TCGA-BS-A0UV	UCEC	TCGA	PTPDGS	DEG_SCF_FBW7_1	0.2778
p.R154I	TCGA-D3-A2JP	SKCM	TCGA	PTPDGS	DEG_SCF_FBW7_1	0.2778
p.R154I	DO222762	COCA	ICGC	PTPDGS	DEG_SCF_FBW7_1	0.2778
p.R154I	DO47407	SKCM	ICGC	PTPDGS	DEG_SCF_FBW7_1	0.2778
p.R154I	DO42793	UCEC	ICGC	PTPDGS	DEG_SCF_FBW7_1	0.2778
p.E141K	TCGA-EA-A43B	CESC	TCGA	PTPDGS	DEG_SCF_FBW7_1	0.1667
p.E141K	DO44384	CESC	ICGC	PTPDGS	DEG_SCF_FBW7_1	0.1667
p.E153A	TCGA-EV-5902	KIRP	TCGA	PTPDGS	DEG_SCF_FBW7_1	0.3056
p.E153A	DO20875	KIRP	ICGC	PTPDGS	DEG_SCF_FBW7_1	0.3056
p.R162C	SIDM01141	Ovarian Carcinoma	GDSC	PTPDGS	DEG_SCF_FBW7_1	0.0556
p.R162C	ACH-000291	Ovarian Cancer	CCLE	PTPDGS	DEG_SCF_FBW7_1	0.0556
p.D150N	SIDM01145	Gastric Carcinoma	GDSC	PTPDGS	DEG_SCF_FBW7_1	0.5821
p.D150N	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	PTPDGS	DEG_SCF_FBW7_1	0.5821
p.P147S	ACH-000588	Myeloma	CCLE	PTPDGS	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96MU7	YTH domain-containing protein 1	DEG_SCF_FBW7_1	147:152	PTPDGS	FBXW7	0.8684	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons