DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PTPDLS
Uniprot ID:
A8K5M9
Source protein:
Uncharacterized protein C15orf62, mitochondrial
Source gene:
C15orf62
Class:
DEG_SCF_FBW7_1
Location:
138:143
E3 ligase:
FBXW7
DEGRON score:
0.9697
ASA_SCORE:
62.5
COIL:
0.798
CONS_SCORE:
0.9919
DSS_SCORE:
0.3326
HELIX:
0.1388
FCONS_SCORE:
1.1691
RIG_SCORE:
0.7309
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D144G
DO228483
BRCA
ICGC
PTPDLS
DEG_SCF_FBW7_1
0.3056
p.V151L
DO229035
LICA
ICGC
PTPDLS
DEG_SCF_FBW7_1
0.1111
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Drug responses associated with C15orf62 mutations
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Cancer
Mutation (In Degron?)
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Drug
IC50
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All proteins holding degron of PTPDLS
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A8K5M9
Uncharacterized protein C15orf62, mitochondrial
DEG_SCF_FBW7_1
138:143
PTPDLS
FBXW7
0.9697
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