DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PTPDLS
Uniprot ID:
A8K5M9
Source protein:
Uncharacterized protein C15orf62, mitochondrial
Source gene:
C15orf62
Class:
DEG_SCF_FBW7_1
Location:
138:143
E3 ligase:
FBXW7
DEGRON score:
0.9697
ASA_SCORE:
62.5
COIL:
0.798
CONS_SCORE:
0.9919
DSS_SCORE:
0.3326
HELIX:
0.1388
FCONS_SCORE:
1.1691
RIG_SCORE:
0.7309
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D144G
DO228483
BRCA
ICGC
PTPDLS
DEG_SCF_FBW7_1
0.3056
p.V151L
DO229035
LICA
ICGC
PTPDLS
DEG_SCF_FBW7_1
0.1111
Drug responses associated with C15orf62 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PTPDLS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A8K5M9
Uncharacterized protein C15orf62, mitochondrial
DEG_SCF_FBW7_1
138:143
PTPDLS
FBXW7
0.9697
More...