DegronMD

Uniprot ID: P48736

Source protein: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Source gene: PIK3CG

Class: DEG_SCF_FBW7_2

Location: 534:539

E3 ligase: FBXW7

DEGRON score: 0.5761

ASA_SCORE: 86.9667

COIL: 0.9173

CONS_SCORE: 0.3981

DSS_SCORE: 0.7171

HELIX: 0.0515

FCONS_SCORE: 0.9004

RIG_SCORE: 0.6054

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R544Q	TCGA-AA-3977	COAD	TCGA	PTPDPE	DEG_SCF_FBW7_2	0.1944
p.R544Q	DO8730	COAD	ICGC	PTPDPE	DEG_SCF_FBW7_2	0.1944
p.R544Q	SIDM01588	Endometrial Carcinoma	GDSC	PTPDPE	DEG_SCF_FBW7_2	0.1944
p.R544Q	ACH-000993	Endometrial/Uterine Cancer	CCLE	PTPDPE	DEG_SCF_FBW7_2	0.1944
p.P538L	TCGA-B0-5075	KIRC	TCGA	PTPDPE	DEG_SCF_FBW7_2	0.6471
p.P538L	DO16406	KIRC	ICGC	PTPDPE	DEG_SCF_FBW7_2	0.6471
p.P538L	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	PTPDPE	DEG_SCF_FBW7_2	0.6471
p.H525N	TCGA-CM-4746	COAD	TCGA	PTPDPE	DEG_SCF_FBW7_2	0.0833
p.H525N	DO7882	COAD	ICGC	PTPDPE	DEG_SCF_FBW7_2	0.0833
p.N549K	TCGA-CZ-5462	KIRC	TCGA	PTPDPE	DEG_SCF_FBW7_2	0.0556
p.N549K	DO19118	KIRC	ICGC	PTPDPE	DEG_SCF_FBW7_2	0.0556
p.R544L	TCGA-HW-7490	LGG	TCGA	PTPDPE	DEG_SCF_FBW7_2	0.1944
p.R544L	DO22155	LGG	ICGC	PTPDPE	DEG_SCF_FBW7_2	0.1944
p.P526L	TCGA-L5-A8NN	ESCA	TCGA	PTPDPE	DEG_SCF_FBW7_2	0.1111
p.M547I	DO222715	COCA	ICGC	PTPDPE	DEG_SCF_FBW7_2	0.1111
p.V543F	DO229025	LICA	ICGC	PTPDPE	DEG_SCF_FBW7_2	0.2222
p.P530T	SIDM02067	Colorectal Carcinoma	GDSC	PTPDPE	DEG_SCF_FBW7_2	0.2222
p.A528V	SIDM00537	Colorectal Carcinoma	GDSC	PTPDPE	DEG_SCF_FBW7_2	0.1667
p.A528V	ACH-000982	Colon/Colorectal Cancer	CCLE	PTPDPE	DEG_SCF_FBW7_2	0.1667
p.A528V	ACH-001345	Colon/Colorectal Cancer	CCLE	PTPDPE	DEG_SCF_FBW7_2	0.1667
p.A528V	GP5d	large_intestine	COSMIC	PTPDPE	DEG_SCF_FBW7_2	0.1667
p.R542W	SIDM00220	Ovarian Carcinoma	GDSC	PTPDPE	DEG_SCF_FBW7_2	0.25
p.R542W	ACH-000962	Ovarian Cancer	CCLE	PTPDPE	DEG_SCF_FBW7_2	0.25
p.R542W	ACH-001145	Ovarian Cancer	CCLE	PTPDPE	DEG_SCF_FBW7_2	0.25
p.R542W	OC-314	ovary	COSMIC	PTPDPE	DEG_SCF_FBW7_2	0.25
p.G540W	ACH-001516	Cervical Cancer	CCLE	PTPDPE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	DEG_SCF_FBW7_2	534:539	PTPDPE	FBXW7	0.5761	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTPDPE

Degron related mutations and impact score

Drug responses associated with PIK3CG mutations

All proteins holding degron of PTPDPE