DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PTPDPS
Uniprot ID:
A2A3N6
Source protein:
Putative PIP5K1A and PSMD4-like protein
Source gene:
PIPSL
Class:
DEG_SCF_FBW7_1
Location:
474:479
E3 ligase:
FBXW7
DEGRON score:
0.9543
ASA_SCORE:
80.4
COIL:
0.9165
CONS_SCORE:
0.2415
DSS_SCORE:
0.7162
HELIX:
0.0592
FCONS_SCORE:
1.0135
RIG_SCORE:
0.602
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with PIPSL mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PTPDPS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A2A3N6
Putative PIP5K1A and PSMD4-like protein
DEG_SCF_FBW7_1
474:479
PTPDPS
FBXW7
0.9543
More...